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Now showing items 11-20 of 499
Hyperlipidemia, oxidative stress, and intima media thickness in children with chronic kidney disease
(Springer, New York, 2013)
The roles of dyslipidemia and oxidative stress in the early phases of atherosclerosis were tested in children with chronic kidney disease (CKD). Intima media thickness of common carotid arteries (cIMT) is used as a measure ...
Association among resistin, adenylate cyclase-associated protein 1 and high-density lipoprotein cholesterol in patients with colorectal cancer: a multi-marker approach, as a hallmark of innovative predictive, preventive, and personalized medicine
(Springer, 2019)
Background: Elevated concentrations of resistin have been reported in colorectal cancer (CRC), but its interactions with adenylate cyclase-associated protein 1 (CAP-1) are largely unexplored. We investigated resistin plasma ...
Risk factors for clopidogrel high on-treatment platelet reactivity in patients with carotid artery stenosis undergoing endarterectomy
(Elsevier, 2016)
Background: Carotid endarterectomy (CEA) is the standard treatment
for carotid stenosis. Dual antiplatelet therapy, including aspirin and
clopidogrel, has a potential role in reducing the risk of stroke after car-
otid ...
Potentially Inappropriate Prescribing in Older Primary Care Patients
(Public Library Science, San Francisco, 2014)
Objectives: The aim of the study was to determine the rate of Potentially Inappropriate Medicines (PIM) and Potential Prescription Omissions (PPO) according to Screening Tool of Older Person's potentially inappropriate ...
Elucidating molecular properties of kappa-carrageenan as critical material attributes contributing to drug dissolution from pellets with a multivariate approach
(Elsevier Science BV, Amsterdam, 2019)
Multivariate data analysis (MVDA) and artificial neural networks (ANN) are supporting statistical methodologies required for successful development and manufacturing of drug products. To address this purpose, a complex ...
Quantitative structure-retention relationships applied to development of liquid chromatography gradient-elution method for the separation of sartans
(Elsevier Science BV, Amsterdam, 2016)
QSRR are mathematically derived relationships between the chromatographic parameters determined for a representative series of analytes in given separation systems and the molecular descriptors accounting for the structural ...
Synthesis of the vitamin E amino acid esters with an enhanced anticancer activity and in silico screening for new antineoplastic drugs
(Elsevier Science BV, Amsterdam, 2016)
Tocopherols and tocotrienols belong to the family of vitamin E (VE) with the well-known antioxidant properties. For certain alpha-tocopherol and gamma-tocotrienol derivatives used as the lead compounds in this study, ...
Application of the design of experiments in optimization of drug layering of pellets with an insight into drug polymer interactions
(Elsevier Science BV, Amsterdam, 2016)
This study consists of two experimental designs. Within the first one, suitable technique for application of model drug onto inactive pellets was evaluated and formulation and process parameters with greatest impact to ...
European views on patients directly obtaining their laboratory test results
(Walter de Gruyter Gmbh, Berlin, 2015)
Background: Medicine is a highly professionalized endeavour, by tradition centred on the authority of physicians. Better education and the advent of the information age cater for increased demands on society in general and ...
Quantitative structure-retention relationship of selected imidazoline derivatives on alpha(1)-acid glycoprotein column
(Elsevier Science BV, Amsterdam, 2016)
The retention behaviour of 22 selected imidazoline drugs and derivatives was investigated on alpha(1)-acid glycoprotein (AGP) column using Sorensen phosphate buffer (pH 7.0) and 2-propanol as organic modifier. Quantitative ...