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Protective role of glutathione reductase in paraquat induced neurotoxicity
(Elsevier Ireland Ltd, Clare, 2012)
Paraquat (PQ), a widely used herbicide is a well-known free radical producing agent. The mechanistic pathways of PQ neurotoxicity were examined by assessing oxidative/nitrosative stress markers. Focus was on the role of ...
An investigation into the effect of formulation variables and process parameters on characteristics of granules obtained by in situ fluidized hot melt granulation
(Elsevier Science BV, Amsterdam, 2012)
The aim of this study was to investigate the influence of binder content, binder particle size, granulation time and inlet air flow rate on granule size and size distribution, granule shape and flowability, as well as on ...
Preparation of carbamazepine-Soluplus (R) solid dispersions by hot-melt extrusion, and prediction of drug-polymer miscibility by thermodynamic model fitting
(Elsevier Science BV, Amsterdam, 2013)
Hot-melt extrusion (HME) is a dust- and solvent-free continuous process enabling the preparation of a variety of solid dosage forms containing solid dispersions of poorly soluble drugs into thermoplastic-polymers. Miscibility ...
Optimization of matrix tablets controlled drug release using Elman dynamic neural networks and decision trees
(Elsevier Science BV, Amsterdam, 2012)
The main objective of the study was to develop artificial intelligence methods for optimization of drug release from matrix tablets regardless of the matrix type. Static and dynamic artificial neural networks of the same ...
Polyaniline and its composites with zeolite ZSM-5 for efficient removal of glyphosate from aqueous solution
(Elsevier Science BV, Amsterdam, 2013)
Nanostructured and granular polyanilines (PANIs) and their composites with zeolite ZSM-5, synthesized by the oxidative polymerization of aniline in water and aqueous solution of sulfuric acid, are evaluated as adsorbents ...
Semisolid self-microemulsifying drug delivery systems (SMEDDSs): Effects on pharmacokinetics of acyclovir in rats
(Elsevier Science BV, Amsterdam, 2018)
Semisolid self-microemulsifying drug delivery system (SMEDDS) with optimized drug loading capacity, stability, dispersibility in aqueous media and in vitro drug release profile, was evaluated in vivo regarding effects on ...
Antibacterial activity of Veronica montana L. extract and of protocatechuic acid incorporated in a food system
(Pergamon-Elsevier Science Ltd, Oxford, 2013)
This study was designed to evaluate the antibacterial activity of the Veronica montana L. water extract and its main phenolic compound, protocatechuic acid. The antibacterial activity was determined by microdilution assay ...
Stepwise optimization approach for improving LC-MS/MS analysis of zwitterionic antiepileptic drugs with implementation of experimental design
(Wiley-Blackwell, Hoboken, 2013)
In this article, a step-by-step optimization procedure for improving analyte response with implementation of experimental design is described. Zwitterionic antiepileptics, namely vigabatrin, pregabalin and gabapentin, were ...
Viscosity-mediated negative food effect on oral absorption of poorly-permeable drugs with an absorption window in the proximal intestine: In vitro experimental simulation and computational verification
(Elsevier Science BV, Amsterdam, 2014)
Concomitant food intake can diminish oral absorption of drugs with limited permeability and an absorption window in the proximal intestine, due to viscosity-mediated decrease in dosage form disintegration time and drug ...
Application of quality by design concepts in the development of fluidized bed granulation and tableting processes
(Elsevier Science Inc, New York, 2013)
This study illustrates the application of experimental design and multivariate data analysis in defining design space for granulation and tableting processes. According to the quality by design concepts, critical quality ...