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Modified local diatomite as potential functional drug carrier-A model study for diclofenac sodium
(Elsevier Science BV, Amsterdam, 2015)
Diatomite makes a promising candidate for a drug carrier because of its high porosity, large surface area, modifiable surface chemistry and biocompatibility. Herein, refined diatomite from Kolubara coal basin, which complied ...
Modeling in the quality by design environment: Regulatory requirements and recommendations for design space and control strategy appointment
(Elsevier Science BV, Amsterdam, 2017)
Mathematical models can be used as an integral part of the quality by design (QbD) concept throughout the product lifecycle for variety of purposes, including appointment of the design space and control strategy, continual ...
Formulation of solid lipid nanoparticles (SLN): The value of different alkyl polyglucoside surfactants
(Elsevier Science BV, Amsterdam, 2014)
Alkyl polyglycosides (APGs) represent a group of nonionic tensides with excellent skin compatibility. Thus they seem to be excellent stabilizers for lipid nanoparticles for dermal application. To investigate this, different ...
Polyhydroxy surfactants for the formulation of lipid nanoparticles (SLN and NLC): Effects on size, physical stability and particle matrix structure
(Elsevier Science BV, Amsterdam, 2011)
The two polyhydroxy surfactants polyglycerol 6-distearate (Plurol (R) Stearique WL1009 - (PS)) and caprylyl/capryl glucoside (Plantacare (R) 810 - (PL)) are a class of PEG-free stabilizers, made from renewable resources. ...
Curcumin-loaded low-energy nanoemulsions as a prototype of multifunctional vehicles for different administration routes: Physicochemical and in vitro peculiarities important for dermal application
(Elsevier Science BV, Amsterdam, 2018)
The objective of this work was to investigate and profoundly characterize low-energy nanoemulsions as multifunctional carriers, with slight reference to dermal administration. An evidence-based approach was offered for ...
Critical quality attributes, in vitro release and correlated in vitro skin permeation-in vivo tape stripping collective data for demonstrating therapeutic (non) equivalence of topical semisolids: A case study of "ready-to-use" vehicles
(Elsevier Science BV, Amsterdam, 2017)
This work aimed to prove the ability of "ready-to-use" topical vehicles based on alkyl polyglucoside-mixed emulsifier (with/without co-solvent modifications) to replace the conventionally used pharmacopoeial bases (e.g., ...
Development of semisolid self-microemulsifying drug delivery systems (SMEDDSs) filled in hard capsules for oral delivery of aciclovir
(Elsevier Science BV, Amsterdam, 2017)
The study aimed to develop semisolid self-microemulsifying drug delivery systems (SMEDDSs) as carriers for oral delivery of aciclovir in hard hydroxypropylmethyl cellulose (HPMC) capsules. Six selfdispersing systems (SD1-SD6) ...
Tacrolimus loaded biocompatible lecithin-based microemulsions with improved skin penetration: Structure characterization and in vitro/in vivo performances
(Elsevier Science BV, Amsterdam, 2017)
In order to improve skin penetration of tacrolimus we aimed to develop potentially non-irritant, lecithin-based microemulsions containing ethanol, isopropanol and/or propylene glycol as cosurfactants, varying caprylic/capric ...
Characterization of gelation process and drug release profile of thermosensitive liquid lecithin/poloxamer 407 based gels as carriers for percutaneous delivery of ibuprofen
(Elsevier Science BV, Amsterdam, 2015)
Suitability of liquid lecithin (i.e., solution of lecithin in soy bean oil with similar to 60% w/w of phospholipids) for formation of gels, upon addition of water solution of poloxamer 407, was investigated, and formulated ...
Investigation of omeprazole stability in oral suspensions for pediatric use prepared extemporaneously from omeprazole capsules
(Elsevier Science BV, Amsterdam, 2016)