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Population exposure-response model of 131I in patients with benign thyroid disease
(Elsevier B.V., 2021)
Purpose: The study aimed to explore the relationship of different exposure measures with 131I therapy response in patients with benign thyroid disease, estimate the variability in the response, investigate possible covariates, ...
Body mass index is independently associated with xanthine oxidase activity in overweight/obese population
(Springer International Publishing, 2020)
Purpose: The pathophysiological mechanism of the relationship between xanthine oxidase (XO) activity and obesity has not been completely elucidated. Since inflammation and oxidative stress are regarded as key determinants ...
A machine learning-based risk stratification model for ventricular tachycardia and heart failure in hypertrophic cardiomyopathy
(Elsevier Ltd, 2021)
Background: Machine learning (ML) and artificial intelligence are emerging as important components of precision medicine that enhance diagnosis and risk stratification. Risk stratification tools for hypertrophic cardiomyopathy ...
Application of machine-learning algorithms for better understanding of tableting properties of lactose co-processed with lipid excipients
(MDPI AG, 2021)
Co-processing (CP) provides superior properties to excipients and has become a reliable option to facilitated formulation and manufacturing of variety of solid dosage forms. Development of directly compressible formulations ...
Phosphatidylserine Exposing Extracellular Vesicles in Pre-eclamptic Patients
(Frontiers Media S.A., 2021)
Background: Pre-eclampsia (P-EC) is associated with systemic inflammation, endothelial dysfunction and hypercoagulability. The role of extracellular vesicles (EVs) in coagulation disturbances affecting the development and ...
Novel Pharmaceutical and Nutraceutical-Based Approaches for Cardiovascular Diseases Prevention Targeting Atherogenic Small Dense LDL
(MDPI, 2022)
Compelling evidence supports the causative link between increased levels of low-density lipoprotein cholesterol (LDL-C) and atherosclerotic cardiovascular disease (CVD) development. For that reason, the principal aim of ...
Performance comparison of nonlinear and linear regression algorithms coupled with different attribute selection methods for quantitative structure - retention relationships modelling in micellar liquid chromatography
(Elsevier, 2020)
In micellar liquid chromatography (MLC), the addition of a surfactant to the mobile phase in excess is accompanied by an alteration of its solubilising capacity and a change in the stationary phase’s properties. As an ...
Interactions between bioactive components determine antioxidant, cytotoxic and nutrigenomic activity of cocoa powder extract
(Elsevier, 2020)
Numerous studies have shown, rather disappointingly, that isolated bioactive phytochemicals are not as biologically effective as natural plant products. Such a discrepancy may be explained by the concept of food synergy, ...
Gelation behavior, drug solubilization capacity and release kinetics of poloxamer 407 aqueous solutions: The combined effect of copolymer, cosolvent and hydrophobic drug
(Elsevier B.V., 2020)
The study elucidated the combined effect of the formulation parameters (the relative contents of the copolymer (poloxamer 407 (P407)), the cosolvent (isopropyl alcohol), and the hydrophobic drug (ibuprofen)) on gelation, ...
Supporting innovative person-centred care in financially constrained environments: The we care exploratory health laboratory evaluation strategy
(MDPI, 2020)
The COST CARES project aims to support healthcare cost containment and improve healthcare quality across Europe by developing the research and development necessary for person-centred care (PCC) and health promotion. This ...