Претраживање
Приказ резултата 21-30 од 206
Application of machine-learning algorithms for better understanding of tableting properties of lactose co-processed with lipid excipients
(MDPI AG, 2021)
Co-processing (CP) provides superior properties to excipients and has become a reliable option to facilitated formulation and manufacturing of variety of solid dosage forms. Development of directly compressible formulations ...
Novel Pharmaceutical and Nutraceutical-Based Approaches for Cardiovascular Diseases Prevention Targeting Atherogenic Small Dense LDL
(MDPI, 2022)
Compelling evidence supports the causative link between increased levels of low-density lipoprotein cholesterol (LDL-C) and atherosclerotic cardiovascular disease (CVD) development. For that reason, the principal aim of ...
Performance comparison of nonlinear and linear regression algorithms coupled with different attribute selection methods for quantitative structure - retention relationships modelling in micellar liquid chromatography
(Elsevier, 2020)
In micellar liquid chromatography (MLC), the addition of a surfactant to the mobile phase in excess is accompanied by an alteration of its solubilising capacity and a change in the stationary phase’s properties. As an ...
Expanding the Accessible Chemical Space of SIRT2 Inhibitors through Exploration of Binding Pocket Dynamics
(American Chemical Society, 2022)
Considerations of binding pocket dynamics are one of the crucial aspects of the rational design of binders. Identification of alternative conformational states or cryptic subpockets could lead to the discovery of completely ...
Curcumin-loaded low-energy nanoemulsions: Linking EPR spectroscopy-analysed microstructure and antioxidant potential with in vitro evaluated biological activity
(Elsevier B.V., 2020)
The objective of this work was to investigate and profoundly characterize low-energy nanoemulsions as multifunctional carriers, with slight reference to dermal administration. An evidence-based approach was offered for ...
Supporting innovative person-centred care in financially constrained environments: The we care exploratory health laboratory evaluation strategy
(MDPI, 2020)
The COST CARES project aims to support healthcare cost containment and improve healthcare quality across Europe by developing the research and development necessary for person-centred care (PCC) and health promotion. This ...
Novel computational approaches to retention modeling in dual hydrophilic interactions/reversed phase chromatography
(Elsevier B.V., 2020)
The mixed-mode chromatographic behavior was estimated for imidazoline and serotonin receptor ligands, and their related compounds on dual hydrophilic/reversed phase stationary phase. The Box-Cox transfor- mation was used ...
Interactions between bioactive components determine antioxidant, cytotoxic and nutrigenomic activity of cocoa powder extract
(Elsevier, 2020)
Numerous studies have shown, rather disappointingly, that isolated bioactive phytochemicals are not as biologically effective as natural plant products. Such a discrepancy may be explained by the concept of food synergy, ...
Revealing the role of high-density lipoprotein in colorectal cancer
(MDPI AG, 2021)
Colorectal cancer (CRC) is a highly prevalent malignancy with multifactorial etiology,which includes metabolic alterations as contributors to disease development. Studies have shownthat lipid status disorders are involved ...
Detecting scaling in phase transitions on the truncated Heisenberg algebra
(Springer Science and Business Media Deutschland GmbH, 2021)
We construct and analyze a phase diagram of a self-interacting matrix field coupled to curvature of the non-commutative truncated Heisenberg space. The model reduces to the renormalizable Grosse-Wulkenhaar model in an ...