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Prikaz rezultata 11-20 od 23
Diabetes and colorectal cancer risk: A new look at molecular mechanisms and potential role of novel antidiabetic agents
(MDPI, 2021)
Epidemiological data have demonstrated a significant association between the presence of type 2 diabetes mellitus (T2DM) and the development of colorectal cancer (CRC). Chronic hyperglycemia, insulin resistance, oxidative ...
Potential applications of NRF2 modulators in cancer therapy
(MDPI, 2020)
The nuclear factor erythroid 2-related factor 2 (NRF2)–Kelch-like ECH-associated protein 1 (KEAP1) regulatory pathway plays an essential role in protecting cells and tissues from oxidative, electrophilic, and xenobiotic ...
Moderate radioprotective role of zeolite in rats / Umerena radioprotektivna uloga zeolita kod pacova
(Belgrade: Military Medical Academy, INI, 2021)
Background/Aim. Exposure of living organisms to γ- radiation results in the overproduction of free radicals. The aim of the study was to test if the subacute administration of micronized zeolite (MZC) accomplishes ...
Oxidative stress status assessment of rats' brains injury following subacute exposure to K-oximes
(Elsevier B.V., 2023)
Oxidative stress status and morphological injuries in the brain of Wistar rats induced by repeated application of selected acetylcholinesterase reactivators - asoxime, obidoxime, K027, K048, K074, and K075 were evaluated. ...
Probiotic reduced the impact of phthalates and bisphenol A mixture on type 2 diabetes mellitus development: Merging bioinformatics with in vivo analysis
(Elsevier, 2021)
Linkage between bis(2-ethylhexyl) phthalate (DEHP), dibutyl phthalate (DBP), and bisphenol A (BPA) coexposure and type 2 diabetes mellitus (T2DM), as well as ability of multi-strained probiotic to reduce DEHP, DBP and BPA ...
New insight into the perplexing toxic features of PCBs: A study of nephrotoxicity in an animal model
(Elsevier Inc, 2023)
The present study investigated the effects of PCBs on the rat kidneys with attention given to the determination critical effect dose (CED) using the Benchmark dose (BMD) approach. Male albino Wistar rats (7 animals per ...
Fluoride subacute testicular toxicity in Wistar rats: Benchmark dose analysis for the redox parameters, essential elements and DNA damage
(Elsevier Ltd, 2022)
Excessive fluoride (F−) levels in the environment could induce different pathological changes, including comorbidities in reproductive functions. Hence, the aim of the present in vivo study was to explore F− subacute ...
Neurotoxic effects of low dose ranges of environmental metal mixture in a rat model: The benchmark approach
(Elsevier Inc., 2024)
Metals exert detrimental effects on various systems within the body, including the nervous system. Nevertheless, the dose-response relationship concerning the administration of low doses of metal mixtures remains inadequately ...
Possible role of lead in breast cancer — a case-control study
(Springer Nature, 2022)
Numerous risk factors have been associated with breast cancer (BC), exposure to metalloestrogen, like lead, being such. Since lead involvement in BC is still equivocal, we focused on lead levels in three compartments of ...
An overview of molecular mechanisms in cadmium toxicity
(Current Opinion in Toxicology, 2020)
Cadmium (Cd), one of the most important environmental pollutants, can cause a number of toxic effects. These effects are the result of more than one mechanisms of toxicity, all interrelated in their complexity. Thus, it ...