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Chaotropic agents in liquid chromatographic method development for the simultaneous analysis of levodopa, carbidopa, entacapone and their impurities
(Elsevier Science BV, Amsterdam, 2013)
The simultaneous pharmaceutical analysis of multi-component drugs represents a challenge due to a large total number of analytes present in the sample. These analytes are not only the active pharmaceutical ingredients, but ...
Insights into functional pharmacology of alpha(1) GABA(A) receptors: how much does partial activation at the benzodiazepine site matter?
(Springer, New York, 2013)
Synthesis of ligands inactive or with low activity at alpha(1) GABA(A) receptors has become the key concept for development of novel, more tolerable benzodiazepine (BZ)-like drugs. WYS8, a remarkably (105 times) alpha(1)-subtype ...
Stepwise optimization approach for improving LC-MS/MS analysis of zwitterionic antiepileptic drugs with implementation of experimental design
(Wiley-Blackwell, Hoboken, 2013)
In this article, a step-by-step optimization procedure for improving analyte response with implementation of experimental design is described. Zwitterionic antiepileptics, namely vigabatrin, pregabalin and gabapentin, were ...
Comparison of interpolation polynomials with divided differences, interpolation polynomials with finite differences, and quadratic functions obtained by the least squares method in modeling of chromatographic responses
(Wiley-Blackwell, Hoboken, 2013)
A novel approach to mathematical modeling of chromatographic responses based on interpolation polynomials with divided differences and with finite differences is discussed. These interpolational techniques as well as ...
DNA Damage in Alzheimer Disease Lymphocytes and Its Relation to Premature Centromere Division
(Karger, Basel, 2013)
While Alzheimer disease (AD) is considered a neurodegenerative disorder, the importance of chromosome instability in non-neuronal cells is equally important, not only for shedding light on the etiology of the disease, but ...
Antibacterial activity of Veronica montana L. extract and of protocatechuic acid incorporated in a food system
(Pergamon-Elsevier Science Ltd, Oxford, 2013)
This study was designed to evaluate the antibacterial activity of the Veronica montana L. water extract and its main phenolic compound, protocatechuic acid. The antibacterial activity was determined by microdilution assay ...
Can Zn supplementation mitigate Cd-induced bioelements disturbances in liver and kidneys?
(Elsevier Ireland Ltd, Clare, 2013)
Effect of magnesium pretreatment on cadmium-induced oxidative stress in mice
(Elsevier Ireland Ltd, Clare, 2013)
Application of quality by design concepts in the development of fluidized bed granulation and tableting processes
(Elsevier Science Inc, New York, 2013)
This study illustrates the application of experimental design and multivariate data analysis in defining design space for granulation and tableting processes. According to the quality by design concepts, critical quality ...
Evaluating the Serbian version of the KIDSCREEN quality-of-life questionnaires: reliability, validity, and agreement between children's and parents' ratings
(Springer, 2013)
To evaluate the psychometric properties of the Serbian set of the KIDSCREEN questionnaires: KIDSCREEN-52, KIDSCREEN-27, and KIDSCREEN-10 index. The study included 330 children (8-18 years) and 314 parents. All completed ...