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Computational study and peptide inhibitors design for the CDK9 - cyclin T1 complex
(Springer, New York, 2013)
Cyclin dependent kinase 9 (CDK9) is a protein that belongs to the cyclin-dependent kinases family, and its main role is in the regulation of the cell transcription processes. Since the increased activity of CDK9 is connected ...
Levetiracetam Interacts Synergistically With Nonsteroidal Analgesics and Caffeine to Produce Antihyperalgesia in Rats
(Churchill Livingstone, Edinburgh, 2013)
Levetiracetam is a novel anticonvulsant with antihyperalgesic efficacy in inflammatory pain. Nonsteroidal analgesics and caffeine, as analgesic adjuvant, are widely used against inflammatory pain. This study characterized ...
Glutathione S-transferase A1, M1, P1 and T1 null or low-activity genotypes are associated with enhanced oxidative damage among haemodialysis patients
(Oxford Univ Press, Oxford, 2013)
Background. Increased oxidative stress is a hallmark of end-stage renal disease (ESRD). Glutathione S-transferases (GST) are involved in the detoxification of xenobiotics and protection of oxidative damage. We hypothesized ...