Претраживање
Приказ резултата 1-10 од 46
Comparative efficacy evaluation of different penetration enhancement strategies for dermal delivery of poorly soluble drugs – A case with sertaconazole nitrate
(Elsevier B.V., 2021)
The aim of this study was to compare the efficacy of different approaches for enhancement of dermal availability of the highly lipophilic antifungal model drug – sertaconazole nitrate (SN). For this purpose, a physical ...
Biopharmaceutical characterization of rebamipide: The role of mucus binding in regional-dependent intestinal permeability
(Elsevier B.V., 2020)
In this study, we aimed to elucidate biopharmaceutical characteristics of the anti-ulcer drug rebamipide, with special emphasis on the influence of gastrointestinal (GI) mucus on rebamipide segmental-dependent permeability ...
Evaluation of exposure time and visible light irradiation in LCD 3D printing of ibuprofen extended release tablets
(Elsevier B.V., 2021)
Liquid crystal display (LCD) 3D printing technology is one of the three currently available photocuring three-dimensional printing technologies. LCD 3D printers usually use wavelengths in the ultraviolent (UV) range. ...
Application of in vitro PAMPA technique and in silico computational methods for blood-brain barrier permeability prediction of novel CNS drug candidates
(Elsevier B.V., 2022)
Permeability assessment of small molecules through the blood-brain barrier (BBB) plays a significant role in the development of effective central nervous system (CNS) drug candidates. Since in vivo methods for BBB permeability ...
Impact of gastrointestinal physiology on drug absorption in special populations––An UNGAP review
(Elsevier, 2020)
The release and absorption profile of an oral medication is influenced by the physicochemical properties of the drug and its formulation, as well as by the anatomy and physiology of the gastrointestinal (GI) tract. During ...
Biopartitioning micellar chromatography as a predictive tool for skin and corneal permeability of newly synthesized 17 beta-carboxamide steroids
(Elsevier Science BV, Amsterdam, 2014)
In this paper, human skin and corneal permeability of twenty-two newly synthesized 17 beta-carboxamide steroids was predicted using biopartitioning micellar chromatography (BMC). These compounds are potential soft ...
Formulation of hydrogel-thickened nonionic microemulsions with enhanced percutaneous delivery of ibuprofen assessed in vivo in rats
(Elsevier Science BV, Amsterdam, 2016)
The study investigated usage of hydrogel of an anionic polymer xanthan gum for design of ibuprofen-loaded hydrogel-thickened microemulsions (HTMs) from the nonionic oil-in-water microemulsion (M). Xanthan gum demonstrated ...
Development of solid lipid microparticles by melt-emulsification/spray-drying processes as carriers for pulmonary drug delivery
(Elsevier B.V., 2021)
The aim of this study was to optimize the parameters of the complex melt-emulsification process coupled with the spray-drying, in order to maintain the balance between solid lipid microparticles (SLMs) powders aerodynamic ...
Tableting of hot-melt coated paracetamol granules: Material tableting properties and quality characteristics of the obtained tablets
(Elsevier B.V., 2020)
Hot-melt coating (HMC) has been recognized as a promising technique in the production of solid dosage forms e.g., HMC of granules can be applied prior to compression in order to obtain modified drug release or taste masking. ...
Synthesis of the vitamin E amino acid esters with an enhanced anticancer activity and in silico screening for new antineoplastic drugs
(Elsevier Science BV, Amsterdam, 2016)
Tocopherols and tocotrienols belong to the family of vitamin E (VE) with the well-known antioxidant properties. For certain alpha-tocopherol and gamma-tocotrienol derivatives used as the lead compounds in this study, ...