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In Vitro modeling of angiotensin-converting enzyme inhibitor's absorption with chromatographic retention data and selected molecular descriptors
(Elsevier Science BV, Amsterdam, 2014)
Set of nine angiotensin-converting enzyme inhibitors (enalapril, quinapril, fosinopril, lisinopril, cilazapril, ramipril, benazepril, perindopril and moexipril) were studied to evaluate the correlation between their ...
Design, synthesis, pharmacological evaluation, QSAR analysis, molecular modeling and ADMET of novel donepezil-indolyl hybrids as multipotent cholinesterase/monoamine oxidase inhibitors for the potential treatment of Alzheimer's disease
(Elsevier France-Editions Scientifiques Medicales Elsevier, Issy-Les-Moulineaux, 2014)
The design, synthesis, and pharmacological evaluation of donepezil indolyl based amines 7-10, amides 12-16, and carboxylic acid derivatives 5 and 11, as multipotent ASS234 analogs, able to inhibit simultaneously cholinesterase ...
An investigation of diclofenac sodium release from cetylpyridinium chloride-modified natural zeolite as a pharmaceutical excipient
(Elsevier Science BV, Amsterdam, 2013)
In this paper, investigations of zeolite - cationic surfactant - drug composites as drug carriers were performed. For that purpose, after adsorption of the model drug - diclofenac sodium (DS) onto composites obtained by ...
Investigation of adsorption and release of diclofenac sodium by modified zeolites composites
(Elsevier Science BV, Amsterdam, 2013)
Results on adsorption of diclofenac sodium (DS) by modified natural zeolite composites at three levels (10,20 and 30 mmol/100 g) of cationic surfactant-hexadecyltrimethylammonium bromide (HB), in a buffer solution, were ...
Modification of Keggin anion structure with ion beams—A new spectroscopic insights into the effects of keV- and MeV-ion beam irradiation on 12-tungstophosphoric acid
(John Wiley and Sons Ltd, 2022)
Ion beam irradiation is a versatile tool for structural modification andengineering of new materials. In this study, 12-tungstophosphoric acid (WPA)films of different thickness were spin-coated on platinized silicon substrate ...
In vitro - in silico - in vivo drug absorption model development based on mechanistic gastrointestinal simulation and artificial neural networks: Nifedipine osmotic release tablets case study
(Elsevier Science BV, Amsterdam, 2014)
In vitro - in vivo correlations (IVIVC) are generally accepted as a valuable tool in modified release formulation development aimed at (i) quantifying the in vivo drug delivery profile and formulation related effects on ...
Glycogen phosphorylase isoenzyme BB plasma kinetics is not related to myocardial ischemia induced by exercise stress echo test
(Walter de Gruyter Gmbh, Berlin, 2013)
Background: Glycogen phosphorylase BB (GPBB) is released from cardiac cells during myocyte damage. Previous studies have shown contradictory results regarding the relation of enzyme release and reversible myocardial ischemia. ...
Structural myocardial alterations in diabetes and hypertension: the role of galectin-3
(Walter de Gruyter Gmbh, Berlin, 2014)
Background: Galectin-3 is a protein widely distributed in the heart, brain and blood vessels, and has a regulatory role in inflammation, immunology and cancer. Many studies demonstrated that the increased level of galectin-3 ...
Effects of derivatization reagents consisting of n-alkyl chloroformate/n-alcohol combinations in LC-ESI-MS/MS analysis of zwitterionic antiepileptic drugs
(Elsevier Science BV, Amsterdam, 2013)
In the current study, three antiepileptic drugs with zwitterionic properties, namely vigabatrin, pregabalin and gabapentin, were chosen as model analytes to undergo derivatization by applying various n-alkyl chloroformat ...
Artificial neural networks modeling in ultra performance liquid chromatography method optimization of mycophenolate mofetil and its degradation products
(Wiley-Blackwell, Hoboken, 2014)
The study of experimental design in conjunction with artificial neural networks for optimization of isocratic ultra performance liquid chromatography method for separation of mycophenolate mofetil and its degradation ...