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Interaction between Omeprazole and Gliclazide in Relation to CYP2C19 Phenotype
(MDPI, 2021)
The antidiabetic drug gliclazide is partly metabolized by CYP2C19, the main enzyme involved in omeprazole metabolism. The aim of the study was to explore the interaction between omeprazole and gliclazide in relation to ...
The Polymorphic Nuclear Factor NFIB Regulates Hepatic CYP2D6 Expression and Influences Risperidone Metabolism in Psychiatric Patients
(John Wiley and Sons Inc, 2022)
The genetic background for interindividual variability of the polymorphic CYP2D6 enzyme activity remains incompletely understood and the role of NFIB genetic polymorphism for this variability was evaluated in this translational ...
Bcs class iv oral drugs and absorption windows: Regional-dependent intestinal permeability of furosemide
(MDPI AG, 2020)
Biopharmaceutical classification system (BCS) class IV drugs (low-solubility low-permeability) are generally poor drug candidates, yet, ~5% of oral drugs on the market belong to this class. While solubility is often ...
Experience and Attitudes Toward Informed Consent in Pharmacy Practice Research: Do Pharmacists Care?
(Springer, Dordrecht, 2017)
The experience and attitudes of pharmacists towards research ethics through pharmacy practice research is largely unknown. This study sought to examine the pharmacists' experience if they were research participants and ...
Long-Term Effects of Maternal Deprivation on the Volume of Dopaminergic Nuclei and Number of Dopaminergic Neurons in Substantia Nigra and Ventral Tegmental Area in Rats
(Frontiers Media S.A., 2020)
Early life adversities leave long-lasting structural and functional consequences on the brain, which may persist later in life. Dopamine is a neurotransmitter that is extremely important in mood and motor control. The aim ...
A Multimarker Approach for the Prediction of Coronary Artery Disease: Cost-Effectiveness Analysis
(Elsevier Science Inc, 2010)
Objectives: Coronary artery disease (CAD), as the leading cause of death, poses a huge economic burden on health-care systems. We used a multi-marker approach to explore discriminative abilities of several lipid, inflammatory, ...
Insight into the formation of glimepiride nanocrystals by wet media milling
(MDPI, 2020)
Nanocrystal formation for the dissolution enhancement of glimepiride was attempted
by wet media milling. Di erent stabilizers were tested and the obtained nanosuspensions were
solidified by spray drying in presence of ...
Long-term effects of chromium on morphological and immunological parameters of Wistar rats
(Elsevier, 2019)
AbstractHexavalent chromium raises high concern because of its wide industrial applications and reported toxicity. Long-term (135 days) oral exposure of Wistar rats to chromium in the form of K2Cr2O7 (exposed group~20 mg/kg/day) ...
Influence of surface coverage of kaolin with surfactant ions on adsorption of ochratoxin A and zearalenone
(Elsevier Ltd, 2021)
A natural kaolin from Serbia was modified with different amounts of octadecyldimethylbenzyl ammonium (ODMBA) - (25, 50 and 90% of kaolin cation exchange capacity). Samples were denoted as OKR-25, OKR-50 and OKR-90. Several ...
Quality benchmarking of smartphone laboratory medicine applications: Comparison of laboratory medicine specialists' and non-laboratory medicine professionals' evaluation
(De Gruyter Open Ltd, 2021)
There are many mobile health applications (apps) now available and some that use in some way laboratory medicine data. Among them, patient-oriented are of the lowest content quality. The aim of this study was to compare ...