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Alterations of acrocentric chromosomes in peripheral blood lymphocytes in patients with Alzheimer's disease
(Srpsko biološko društvo, Beograd, i dr., 2013)
While Alzheimer's disease (AD) is primarily considered to be a neurodegenerative disorder, there is much evidence supporting the idea that it is also a systematic disease, so the occurrence of genomic instability in cells ...
Gonadal hormone dependent developmental plasticity of catecholamine:beta 2-adrenoceptor signaling complex in male rat thymus: Putative implications for thymopoiesis
(Elsevier Science BV, Amsterdam, 2013)
The study was undertaken considering that: i) androgens affect beta(2)-adrenoceptor (AR)-mediated catecholamine (CA) action in many tissues; and ii) peripubertal changes in both circulating androgen and thymic CA levels ...
Adrenal hormone deprivation affects macrophage catecholamine metabolism and 2-adrenoceptor density, but not propranolol stimulation of tumour necrosis factor- production
(Wiley-Blackwell, Hoboken, 2013)
New Findings center dot What is the central question of this study? Glucocorticoids modulate extraglandular catecholamine metabolism and adrenoceptor expression in many cell types. Catecholamines modulate the production ...
Chaotropic agents in liquid chromatographic method development for the simultaneous analysis of levodopa, carbidopa, entacapone and their impurities
(Elsevier Science BV, Amsterdam, 2013)
The simultaneous pharmaceutical analysis of multi-component drugs represents a challenge due to a large total number of analytes present in the sample. These analytes are not only the active pharmaceutical ingredients, but ...
Seasonal variations in the chemical composition and fatty acid composition of selected fish species from the danube river
(Akademiai Kiado Rt, Budapest, 2013)
The influence of seasonal variations on the chemical composition and composition of fatty acids in five commercially important freshwater fish species from the Danube: white bream, bream, vimba, zope, and Prussian carp, ...
Relative Liver Weight in Rats Subacutely Exposed to Polychlorinated Biphenyls
(NATO Science for Peace and Security Series C: Environmental Security, 2013)
Polychlorinated biphenyls (PCBs) are pollutants abundantly present in the environment. Before they were banned, commercial mixtures of PCBs had been produced in many countries and were used for a number of technical purposes. ...
Hematological, oxidative stress, and immune status profiling in elite combat sport athletes
(Lippincott Williams & Wilkins, Philadelphia, 2013)
The aim of this study was to profile hematological, oxidative stress, and immunological parameters in male athletes who practiced combat sports and to determine whether the type of combat sport influenced the measured ...
Insights into functional pharmacology of alpha(1) GABA(A) receptors: how much does partial activation at the benzodiazepine site matter?
(Springer, New York, 2013)
Synthesis of ligands inactive or with low activity at alpha(1) GABA(A) receptors has become the key concept for development of novel, more tolerable benzodiazepine (BZ)-like drugs. WYS8, a remarkably (105 times) alpha(1)-subtype ...
Sesquiterpene lactones from the extracts of two Balkan endemic Laserpitium species and their cytotoxic activity
(Pergamon-Elsevier Science Ltd, Oxford, 2013)
Chloroform extracts of the underground parts of two Balkan endemic Laserpitium species, Laserpitium zernyi Hayek and Laserpitium ochridanum Micevski, were chemically investigated. Five unknown guaianolides from the class ...
Population pharmacokinetics of topiramate in adult patients with epilepsy using nonlinear mixed effects modelling
(Elsevier Science BV, Amsterdam, 2013)
The objective of the study was to develop population pharmacokinetic model of topiramate (TPM) using nonlinear mixed effects modelling approach. Data were collected from 78 adult epileptic patients on mono- or co-therapy ...