Pretraživanje
Prikaz rezultata 1-10 od 656
Total plasma protein effect on tacrolimus elimination in kidney transplant patients - Population pharmacokinetic approach
(Elsevier Science BV, Amsterdam, 2014)
Data from routine therapeutic drug monitoring of 105 adult kidney transplant recipients were used for population pharmacokinetic analysis which was performed using a non-linear mixed-effects modeling. The effect of demographic ...
L-FABP can be an early marker of acute kidney injury in children
(Springer, New York, 2013)
Acute kidney injury (AKI) is a common postoperative complication following cardiopulmonary bypass (CPB) surgery. New biomarkers to identify patients with early AKI (before increases in serum creatinine) are needed to ...
17 beta-carboxamide steroids - in vitro prediction of human skin permeability and retention using PAMPA technique
(Elsevier Science BV, Amsterdam, 2014)
In this paper, twenty-two 17 beta-carboxamide steroids were synthesized from five corticosteroids (hydrocortisone, prednisolone, methylprednisolone, dexamethasone and betamethasone) in two steps. The first step was periodic ...
Time-dependent changes of myeloperoxidase in relation to in-hospital mortality in patients with the first anterior ST-segment elevation myocardial infarction treated by primary percutaneous coronary intervention
(Pergamon-Elsevier Science Ltd, Oxford, 2012)
Objectives: To analyze the prognostic value of myeloperoxidase (MPO) in relation to in-hospital mortality and to identify the optimum time point for sampling in patients with the first anterior ST-segment elevation myocardial ...
Vigabatrin in dried plasma spots: Validation of a novel LC-MS/MS method and application to clinical practice
(Elsevier Science BV, Amsterdam, 2014)
This paper presents a LC-MS/MS method for the determination of antiepileptic drug vigabatrin in dried plasma spots (DPS). Due to its zwitterionic chemical structure, a pre-column derivatization procedure was performed, ...
Testing the capability of a polynomial-modified gaussian model in the description and simulation of chromatographic peaks of amlodipine and its impurity in ion-interaction chromatography
(Wiley-VCH Verlag GMBH, Weinheim, 2014)
In this paper, the capability of a polynomial-modified Gaussian model to relate the peak shape of basic analytes, amlodipine, and its impurity A, with the change of chromatographic conditions was tested. For the accurate ...
Determination of chromium in Mentha piperita L. and soil by graphite furnace atomic absorption spectrometry after sequential extraction and microwave-assisted acid digestion to assess potential bioavailability
(Pergamon-Elsevier Science Ltd, Oxford, 2010)
Analysis of chromium in Mentha piperita and the soil where it is cultivated was done. The capacity of soil for chromium immobilization and the capacity of M. piperita L., to control its uptake were analyzed by spiking the ...
Risk characterization for mercury, dichlorodiphenyltrichloroethane and polychlorinated biphenyls associated with fish consumption in Serbia
(Pergamon-Elsevier Science Ltd, Oxford, 2011)
The aim of this work was to assess the risk due to mercury (Hg), dichlorodiphenyltrichloroethane (DDT) and non-dioxin-like polychlorinated biphenyls (ndl PCBs) intake via fish consumption in Serbia. We have developed 24 ...
Characterization and evaluation of solid self-microemulsifying drug delivery systems with porous carriers as systems for improved carbamazepine release
(Elsevier Science BV, Amsterdam, 2012)
The purpose of this study was to investigate solid self-microemulsifying drug delivery system (SSMEDDS), as potential delivery system for poorly water soluble drug carbamazepine (CBZ). Self-microemulsifying drug delivery ...
Vasodilatory effects of a variety of positive allosteric modulators of GABAA receptors on rat thoracic aorta
(Elsevier B.V., 2021)
Different subtypes of GABAA (gamma-aminobutyric acid A) receptors, through their specific regional and cellular localization, are involved in the manifestation of various functions, both at the central and peripheral levels. ...