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Intrastriatal pre-treatment with L-NAME protects rats from diquat neurotoxcity
(Inst Agricultural Medicine, Lublin, 2012)
Introduction: Contact herbicide diquat (DQ), redox cycling compound, mediates its systemic toxicity throughout the enlarged production of free radicals. Target organs are liver and kidney in humans. To-date, the mechanism ...
3d printed buccal films for prolonged-release of propranolol hydrochloride: Development, characterization and bioavailability prediction
(MDPI, 2021)
Gelatin-polyvinylpyrrolidone (PVP) and gelatin-poly(vinyl alcohol) (PVA) mucoadhesive buccal films loaded with propranolol hydrochloride (PRH) were prepared by semi-solid extrusion 3D printing. The aim of this study was ...
Detecting scaling in phase transitions on the truncated Heisenberg algebra
(Springer Science and Business Media Deutschland GmbH, 2021)
We construct and analyze a phase diagram of a self-interacting matrix field coupled to curvature of the non-commutative truncated Heisenberg space. The model reduces to the renormalizable Grosse-Wulkenhaar model in an ...
Significantly lower CYP2D6 metabolism measured as the O/N-desmethylvenlafaxine metabolic ratio in carriers of CYP2D6*41 versus CYP2D6*9 or CYP2D6*10: a study on therapeutic drug monitoring data from 1003 genotyped Scandinavian patients
(Wiley, Hoboken, 2019)
Aims CYP2D6*9, CYP2D6*10 and CYP2D6*41 are the most frequent reduced-function CYP2D6 alleles in Caucasians. Despite lacking in vivo evidence, they are collectively classified with an enzyme activity score of 0.5. Thus, the ...
Specific changes in the mammalian gut microbiome as a biomarker for oxytocin-induced behavioral changes
(MDPI, 2021)
Humans are colonized by bacteria, fungi, archaea, and viruses, which are collectively referred to as the microbiome. Most of the microbiome resides in the gut and may easily be investigated via stool sampling and subsequent ...
Polyhydroxy surfactants for the formulation of lipid nanoparticles (SLN and NLC): Effects on size, physical stability and particle matrix structure
(Elsevier Science BV, Amsterdam, 2011)
The two polyhydroxy surfactants polyglycerol 6-distearate (Plurol (R) Stearique WL1009 - (PS)) and caprylyl/capryl glucoside (Plantacare (R) 810 - (PL)) are a class of PEG-free stabilizers, made from renewable resources. ...
Validity of the Food Frequency Questionnaire Assessing the Folate Intake in Women of Reproductive Age Living in a Country without Food Fortification: Application of the Method of Triads
(MDPI, Basel, 2017)
The study aimed to examine the external validity of the Folate Food Frequency Questionnaire (F-FFQ) designed for assessing the folate intake in Serbian women of reproductive age. The F-FFQ was tested against repeated 24 h ...
PWZ-029, an inverse agonist selective for alpha(5) GABA(A) receptors, improves object recognition, but not water-maze memory in normal and scopolamine-treated rats
(Elsevier Science BV, Amsterdam, 2013)
Inverse agonism at the benzodiazepine site of alpha(5) subunit-containing GABA(A) receptors is an attractive approach for the development of putative cognition-enhancing compounds, which are still far from clinical ...
Circulating resistin protein and mRNA concentrations and clinical severity of coronary artery disease
(Croatian Soc Medical Biochemistry & Laboratory Medicine, Zagreb, 2015)
Introduction: Previous studies have implicated a strong link between circulating plasma resistin and coronary artery disease (CAD). The aim of this study was to evaluate the differences in peripheral blood mononuclear cells ...
Sex Bias in Pathogenesis of Autoimmune Neuroinflammation: Relevance for Dimethyl Fumarate Immunomodulatory/Anti-oxidant Action
(Springer, New York, 2018)
In the present study, upon showing sexual dimorphism in dimethyl fumarate (DMF) efficacy to moderate the clinical severity of experimental autoimmune encephalomyelitis (EAE) in Dark Agouti rats, cellular and molecular ...