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Can Zeolite-Supporting Acridines Boost Their Anticancer Performance?
(MDPI, 2023)
Acridine and its derivatives (9-chloroacridine and 9-aminoacridine) are investigated here, supported on FAU type zeolite Y, as a delivery system of anticancer agents. FTIR/Raman spectroscopy and electron microscopy revealed ...
Drugs with a negative impact on cognitive function (Part 1): chronic kidney disease as a risk factor
(Oxford University Press ( Oxford Academic), 2023)
People living with chronic kidney disease (CKD) frequently suffer from mild cognitive impairment and/or other
neurocognitive disorders. This review in two parts will focus on adverse drug reactions resulting in cognitive ...
Asymmetric Dimethylarginine Is a Marker of Endothelial Dysfunction in Thrombotic Antiphospholipid Syndrome Patients
(MDPI, 2022)
Objective: The potential contribution of asymmetric dimethylarginine (ADMA) and high-sensitivity C reactive protein (hsCRP) to endothelial dysfunction in APS patients has not been studied in detail, until now. The study ...
In-Depth Analysis of Physiologically Based Pharmacokinetic (PBPK) Modeling Utilization in Different Application Fields Using Text Mining Tools
(MDPI, 2023)
In the past decade, only a small number of papers have elaborated on the application of physiologically based pharmacokinetic (PBPK) modeling across different areas. In this review, an in-depth analysis of the distribution ...
SIRT2i_Predictor: A Machine Learning-Based Tool to Facilitate the Discovery of Novel SIRT2 Inhibitors
(MDPI, 2023)
A growing body of preclinical evidence recognized selective sirtuin 2 (SIRT2) inhibitors as novel therapeutics for treatment of age-related diseases. However, none of the SIRT2 inhibitors have reached clinical trials yet. ...
Approximate treatment of noncommutative curvature in quartic matrix model
(Springer Science and Business Media Deutschland GmbH, 2023)
We study a Hermitian matrix model with the standard quartic potential amended by a tr(RΦ2) term for fixed external matrix R. This is motivated by a curvature term in the truncated Heisenberg algebra formulation of the ...
Synthesis, Evaluation of Enzyme Inhibition and Redox Properties of Potential Dual COX-2 and 5-LOX Inhibitors
(MDPI, 2023)
Various dual inhibitors of COX-2 and 5-LOX enzymes have been developed so far in order to obtain more effective and safer anti-inflammatory drugs. The aim of this study was to design and synthesize new dual COX-2 and 5-LOX ...
Subacute Exposure to Low Pb Doses Promotes Oxidative Stress in the Kidneys and Copper Disturbances in the Liver of Male Rats
(MDPI, 2023)
Recent data indicate that lead (Pb) can induce adverse effects even at low exposure levels. Moreover, the corresponding mechanisms of low Pb toxicity have not been well identified. In the liver and the kidneys, Pb was found ...
Development of Analytical Quality by Design Compliant Chaotropic Chromatography Method for Ziprasidone and Its Five Impurities Determination
(MDPI, 2023)
In this study, an AQbD-compliant chaotropic chromatography method for ziprasidone and the determination of its five impurities was developed. The influence of critical method parameters (initial and final methanol fraction ...
Nickel as a potential disruptor of thyroid function: benchmark modelling of human data
(Frontiers Media SA, 2023)
Introduction: Nickel (Ni) is one of the well-known toxic metals found in the environment. However, its influence on thyroid function is not explored enough. Hence, the aim of this study was to analyse the potential of Ni ...