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Application of machine-learning algorithms for better understanding of tableting properties of lactose co-processed with lipid excipients
(MDPI AG, 2021)
Co-processing (CP) provides superior properties to excipients and has become a reliable option to facilitated formulation and manufacturing of variety of solid dosage forms. Development of directly compressible formulations ...
The Impact of the Oil Phase Selection on Physicochemical Properties, Long-Term Stability, In Vitro Performance and Injectability of Curcumin-Loaded PEGylated Nanoemulsions
(MDPI, 2022)
A nanotechnology-based approach to drug delivery presents one of the biggest trends in biomedical science that can provide increased active concentration, bioavailability, and safety compared to conventional drug-delivery ...
Numerical Modeling of Particle Dynamics Inside a Dry Powder Inhaler
(MDPI, 2022)
The development of novel dry powders for dry powder inhalers (DPIs) requires the in vitro assessment of DPI aerodynamic performance. As a potential complementary method, in silico numerical simulations can provide additional ...
Overcoming the low oral bioavailability of deuterated pyrazoloquinolinone ligand dk-i-60-3 by nanonization: A knowledge-based approach
(MDPI AG, 2021)
Poor water solubility of new chemical entities is considered as one of the main obstacles in drug development, as it usually leads to low bioavailability after administration. To overcome these problems, the selection of ...
Targeting Histone Deacetylases: Opportunities for Cancer Treatment and Chemoprevention
(MDPI, 2022)
The dysregulation of gene expression is a critical event involved in all steps of tumorigenesis. Aberrant histone and non-histone acetylation modifications of gene expression due to the abnormal activation of histone ...
Chemical vs. Physical Methods to Improve Dermal Drug Delivery: A Case Study with Nanoemulsions and Iontophoresis
(MDPI, 2022)
So far, various approaches have been proposed to improve dermal drug delivery. The
use of chemical penetration enhancers has a long history of application, while methods based on
the electrical current (such as iontophoresis) ...
An investigation into mechanical properties and printability of potential substrates for inkjet printing of orodispersible films
(MDPI, 2021)
Inkjet printing is novel approach in drug manufacturing that enables dispensing precisevolumes of ink onto substrates. Optimal substrate properties including suitable mechanical charac-teristic are recognized as crucial ...