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Multipotent cholinesterase/monoamine oxidase inhibitors for the treatment of Alzheimer's disease: design, synthesis, biochemical evaluation, ADMET, molecular modeling, and QSAR analysis of novel donepezil-pyridyl hybrids
(Dove Medical Press Ltd, Albany, 2014)
The design, synthesis, and biochemical evaluation of donepezil-pyridyl hybrids (DPHs) as multipotent cholinesterase (ChE) and monoamine oxidase (MAO) inhibitors for the potential treatment of Alzheimer's disease (AD) is ...
Distribution of Low-Density Lipoprotein and High-Density Lipoprotein Subclasses in Patients With Sarcoidosis
(Coll Amer Pathologists, Northfield, 2013)
Context.-Systemic inflammatory diseases are associated with proatherogenic lipoprotein profile, but there is a lack of information regarding overall distributions of lipoprotein subclasses in sarcoidosis. Objective.-To ...
Specific changes in the mammalian gut microbiome as a biomarker for oxytocin-induced behavioral changes
(MDPI, 2021)
Humans are colonized by bacteria, fungi, archaea, and viruses, which are collectively referred to as the microbiome. Most of the microbiome resides in the gut and may easily be investigated via stool sampling and subsequent ...
Massage-like stroking boosts the immune system in mice
(Nature Publishing Group, London, 2015)
Recent clinical evidence suggests that the therapeutic effect of massage involves the immune system and that this can be exploited as an adjunct therapy together with standard drug-based approaches. In this study, we ...
Cholesterol homeostasis is dysregulated in women with preeclampsia
(Medycyna Praktyczna Cholerzyn, 2021)
Introduction The link between preeclampsia and dyslipidemia has been established. Even though lipid profile parameters have been intensively investigated in the pathology of preeclampsia, their accurate molecular mechanisms ...
Effect of Magnesium Supplementation on the Distribution Patterns of Zinc, Copper, and Magnesium in Rabbits Exposed to Prolonged Cadmium Intoxication
(Hindawi Publishing Corporation, New York, 2012)
The present study is designed to investigate whether magnesium (Mg) supplementation may prevent Cd-induced alterations in zinc (Zn), copper (Cu), and magnesium (Mg) status in rabbits. For this purpose, the concentrations ...
Sex differences in Tfh cell help to B cells contribute to sexual dimorphism in severity of rat collagen-induced arthritis
(Springer Nature, 2020)
The study examined germinal centre (GC) reaction in lymph nodes draining inflamed joints and adjacent tissues (dLNs) in male and female Dark Agouti rat collagen type II (CII)-induced arthritis (CIA) model of rheumatoid ...
Design Space Approach in Optimization of Fluid Bed Granulation and Tablets Compression Process
(Hindawi Publishing Corporation, New York, 2012)
The aim of this study was to optimize fluid bed granulation and tablets compression processes using design space approach. Type of diluent, binder concentration, temperature during mixing, granulation and drying, spray ...
Dusp16 deficiency causes congenital obstructive hydrocephalus and brain overgrowth by expansion of the neural progenitor pool
(Frontiers Media S.A., 2017)
Hydrocephalus can occur in children alone or in combination with other neurodevelopmental disorders that are often associated with brain overgrowth. Despite the severity of these disorders, the molecular and cellular ...
Chemical characterization, antioxidant and antimicrobial properties of goji berries cultivated in Serbia
(MDPI AG, 2020)
Since the fruits of Lycium L. species (Fructus lycii, goji berries) are promoted as a “superfood”
with plenty of health benefits, there is extensive research interest in their nutritional and phytochemical
composition. ...