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Приказ резултата 1-10 од 31
Optimization of formulation and process parameters for the production of carvedilol nanosuspension by wet media milling
(Elsevier Science BV, Amsterdam, 2018)
The aim of this study is to develop nanosuspension of carvedilol (CRV) by wet media milling. Concentration of polymeric stabilizer (hydroxypropyl cellulose-HPC-SL), milling speed and size of milling beads were identified ...
Investigation of surfactant/cosurfactant synergism impact on ibuprofen solubilization capacity and drug release characteristics of nonionic microemulsions
(Elsevier Science BV, Amsterdam, 2012)
The current study investigates the performances of the multicomponent mixtures of nonionic surfactants regarding the microemulsion stabilisation, drug solubilization and in vitro drug release kinetic. The primary surfactant ...
An investigation into the usefulness of different empirical modeling techniques for better control of spray-on fluidized bed melt granulation
(Elsevier Science BV, Amsterdam, 2015)
Melt granulation in fluid bed processors is an emerging technique, but literature data regarding the modeling of this granulation method are lacking. In the present study different techniques (response surface analysis, ...
Characterization and evaluation of solid self-microemulsifying drug delivery systems with porous carriers as systems for improved carbamazepine release
(Elsevier Science BV, Amsterdam, 2012)
The purpose of this study was to investigate solid self-microemulsifying drug delivery system (SSMEDDS), as potential delivery system for poorly water soluble drug carbamazepine (CBZ). Self-microemulsifying drug delivery ...
Optimization of matrix tablets controlled drug release using Elman dynamic neural networks and decision trees
(Elsevier Science BV, Amsterdam, 2012)
The main objective of the study was to develop artificial intelligence methods for optimization of drug release from matrix tablets regardless of the matrix type. Static and dynamic artificial neural networks of the same ...
In silico modeling of in situ fluidized bed melt granulation
(Elsevier Science BV, Amsterdam, 2014)
Fluidized bed melt granulation has recently been recognized as a promising technique with numerous advantages over conventional granulation techniques. The aim of this study was to evaluate the possibility of using response ...
Parenteral nanoemulsions of risperidone for enhanced brain delivery in acute psychosis: Physicochemical and in vivo performances
(Elsevier Science BV, Amsterdam, 2017)
This work aimed to deepen the lately acquired knowledge about parenteral nanoemulsions as carriers for brain delivery of risperidone, a poorly water-soluble antipsychotic drug, through establishing the prospective relationship ...
An investigation into the effect of formulation variables and process parameters on characteristics of granules obtained by in situ fluidized hot melt granulation
(Elsevier Science BV, Amsterdam, 2012)
The aim of this study was to investigate the influence of binder content, binder particle size, granulation time and inlet air flow rate on granule size and size distribution, granule shape and flowability, as well as on ...
From smart materials to advanced drug delivery systems Preface
(Elsevier Science BV, Amsterdam, 2017)
Biocompatible microemulsions of a model NSAID for skin delivery: A decisive role of surfactants in skin penetration/irritation profiles and pharmacokinetic performance
(Elsevier Science BV, Amsterdam, 2015)
To elaborate the decisive role of surfactants in promotion of aceclofenac' skin absorption, potentially avoiding irritation, we developed non-ionic microemulsions varying natural or synthetic surfactants: sucrose esters ...