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Novel Pharmaceutical and Nutraceutical-Based Approaches for Cardiovascular Diseases Prevention Targeting Atherogenic Small Dense LDL
(MDPI, 2022)
Compelling evidence supports the causative link between increased levels of low-density lipoprotein cholesterol (LDL-C) and atherosclerotic cardiovascular disease (CVD) development. For that reason, the principal aim of ...
Expanding the Accessible Chemical Space of SIRT2 Inhibitors through Exploration of Binding Pocket Dynamics
(American Chemical Society, 2022)
Considerations of binding pocket dynamics are one of the crucial aspects of the rational design of binders. Identification of alternative conformational states or cryptic subpockets could lead to the discovery of completely ...
Positive modulation of α5GABAA receptors leads to dichotomous effects in rats on memory pattern and GABRA5 expression in prefrontal cortex and hippocampus
(Elsevier B.V., 2022)
Positive allosteric modulators (PAMs) of α5GABAA receptors (α5GABAARs) are emerging as potential therapeutics for a range of neuropsychiatric disorders. However, their role in memory processing of healthy animals is not ...
Compliance of the POCT method with the fully automated method for HbA1c determination / Usklađenost POCT metode sa potpuno automatizovanom metodom za određivanje HbA1c
(Pharmaceutical Association of Serbia, 2022)
Previous research suggests that point-of-care (POCT) determination of glycated hemoglobin (HbA1c) is a diagnostic test that can be an adequate alternative to measuring HbA1c in the laboratory. The main goal of this study ...
α6-Containing GABAA Receptors: Functional Roles and Therapeutic Potentials
(American Society for Pharmacology and Experimental Therapy, 2022)
GABAA receptors containing the α6 subunit are highly expressed in cerebellar granule cells and less abundantly in many other neuronal and peripheral tissues. Here, we for the first time summarize their importance for the ...
Telepharmacy service experience during the COVID-19 pandemic in the Republic of Srpska, Bosnia and Herzegovina
(John Wiley and Sons Inc, 2022)
The COVID-19 pandemic exerted a profound impact on health systems worldwide. Moreover, significant concerns were raised in terms of middle- and long-term consequences of postponing care in non-COVID patients. The primary ...
Antiallergic Treatment of Bariatric Patients: Potentially Hampered Solubility/Dissolution and Bioavailability of Loratadine, but Not Desloratadine, Post-Bariatric Surgery
(American Chemical Society, 2022)
Gastrointestinal anatomical/physiological changes after bariatric surgery influence variables affecting the fate of drugs after ingestion, and medication management of these patients requires a thorough and complex mechanistic ...
Impact of the novel CYP2C:TG haplotype and CYP2B6 variants on sertraline exposure in a large patient population
(John Wiley and Sons Inc, 2022)
Sertraline is a commonly used SSRI antidepressant drug, metabolized by CYP2C19 and CYP2B6, that exhibits a substantial interindividual variation in clinical response, of which only a part can be attributed to known genetic ...
Influence of spray-drying process on properties of chitosan/xanthan gum polyelectrolyte complexes as carriers for oral delivery of ibuprofen / Uticaj postupka sušenja raspršivanjem na svojstva polielektrolitnih kompleksa hitozana i ksantan gume kao nosača za peroralnu isporuku ibuprofena
(Savez farmaceutskih udruženja Srbije, 2022)
Polyelectrolyte complexes (PECs) are attractive carriers with recognized potential to
enhance oral delivery of poorly soluble high-dosed low-molecular-weight drugs. The formulation
of solid oral dosage forms requires the ...
Atherosclerosis Development and Progression: The Role of Atherogenic Small, Dense LDL
(MDPI, 2022)
Atherosclerosis is responsible for large cardiovascular mortality in many countries globally. It has been shown over the last decades that the reduction of atherosclerotic progression is a critical factor for preventing ...