Search
Now showing items 1-10 of 32
Abnormal development of monoaminergic neurons is implicated in mood fluctuations and bipolar disorder
(Nature Publishing Group, 2015)
Subtle mood fluctuations are normal emotional experiences, whereas drastic mood swings can be a manifestation of bipolar disorder (BPD). Despite their importance for normal and pathological behavior, the mechanisms underlying ...
Optimization of technological procedure for amygdalin isolation from plum seeds (Pruni domesticae semen)
(Frontiers Media Sa, Lausanne, 2015)
The process of amygdalin extraction from plum seeds was optimized using central composite design (CCD) and multilayer perceptron (MLP). The effect of time, ethanol concentration, solid-to-liquid ratio, and temperature on ...
Critical assessment and integration of separate lines of evidence for risk assessment of chemical mixtures
(Springer Verlag, 2019)
Humans are exposed to multiple chemicals on a daily basis instead of to just a single chemical, yet the majority of existing toxicity data comes from single-chemical exposure. Multiple factors must be considered such as ...
Premature Centromere Division of Metaphase Chromosomes in Peripheral Blood Lymphocytes of Alzheimer's Disease Patients: Relation to Gender and Age
(Oxford Univ Press Inc, Cary, 2010)
Chromosomal alterations are a feature of both aging and Alzheimer's disease (AD). This study examined if premature centromere division (PCD), a chromosomal instability indicator increased in AD, is correlated with aging ...
A Multimarker Approach for the Prediction of Coronary Artery Disease: Cost-Effectiveness Analysis
(Elsevier Science Inc, 2010)
Objectives: Coronary artery disease (CAD), as the leading cause of death, poses a huge economic burden on health-care systems. We used a multi-marker approach to explore discriminative abilities of several lipid, inflammatory, ...
N-Methyl-N-((1-methyl-5-(3-(1-(2-methylbenzyl)piperidin-4yl)propoxy)-1H-indol-2-yl)methyl)prop-2-yn-1-amine, a New Cholinesterase and Monoamine Oxidase Dual
(Amer Chemical Soc, Washington, 2014)
On the basis of N-((5-(3-(1-benzylpiperidin-4-yl)propoxy)-1-methyl-1H-indol-2-yl)methyl)-N-methylprop-2-yn-1-amine (II, ASS234) and QSAR predictions, in this work we have designed, synthesized, and evaluated a number of ...
International Union of Basic and Clinical Pharmacology. CVI: GABAA Receptor Subtype- and Function-selective Ligands: Key Issues in Translation to Humans
(Amer Soc Pharmacology Experimental Therapeutics, Bethesda, 2018)
GABAA receptors are themajor inhibitory transmitter receptors in the brain. They are ligand-gated chloride channels and the site of action of benzodiazepines, barbiturates, neuroactive steroids, anesthetics, and convulsants. ...
Association of acute Babesia canis infection and serum lipid, lipoprotein, and apoprotein concentrations in dogs
(Blackwell Publishing Inc., 2019)
Background: Babesia canis infection induces a marked acute phase response (APR) that might be associated with alteration in lipid and lipoprotein metabolism and disease prognosis. Hypothesis: Dogs with B. canis-induced APR ...
Triggered dynamics in a model of different fault creep regimes
(Nature Publishing Group, London, 2014)
The study is focused on the effect of transient external force induced by a passing seismic wave on fault motion in different creep regimes. Displacement along the fault is represented by the movement of a spring-block ...
The role of communication and health literacy on patient safety in public pharmacies in the Republic of Srpska
(Elsevier Science Inc, 2013)
Health literacy is the skill (social and cognitive) that determines the motivation
and ability of the person to receive, understand and use information in order
to improve and maintain good health. Communication between ...