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Quantitative structure-retention relationships applied to development of liquid chromatography gradient-elution method for the separation of sartans
(Elsevier Science BV, Amsterdam, 2016)
QSRR are mathematically derived relationships between the chromatographic parameters determined for a representative series of analytes in given separation systems and the molecular descriptors accounting for the structural ...
Advancement in optimization tactic achieved by newly developed chromatographic response function: Application to LC separation of raloxifene and its impurities
(Elsevier Science BV, Amsterdam, 2011)
In this paper a new chromatographic response function (CRF) is designed and proposed for utilization in the optimization strategies. The function capability to represent the overall quality of a experimentally obtained ...
Improved chromatographic response function in HILIC analysis: Application to mixture of antidepressants
(Elsevier Science BV, Amsterdam, 2012)
This paper presents exploration of chromatographic behavior in HILIC system by experimental design and improved chromatographic response function denoted as N-CRF*. As a model mixture six antidepressants were chosen: ...
Effects of derivatization reagents consisting of n-alkyl chloroformate/n-alcohol combinations in LC-ESI-MS/MS analysis of zwitterionic antiepileptic drugs
(Elsevier Science BV, Amsterdam, 2013)
In the current study, three antiepileptic drugs with zwitterionic properties, namely vigabatrin, pregabalin and gabapentin, were chosen as model analytes to undergo derivatization by applying various n-alkyl chloroformat ...
Profiling differences in chemical composition of brain structures using Raman spectroscopy
(Elsevier Science BV, Amsterdam, 2013)
Raman spectroscopy enables non-invasive investigation of chemical composition of biological tissues. Due to similar chemical composition, the analysis of Raman spectra of brain structures and assignment of their spectral ...
Quantitative structure retention relationships of azole antifungal agents in reversed-phase high performance liquid chromatography
(Elsevier Science BV, Amsterdam, 2012)
Artificial neural network (ANN) is a learning system based on a computational technique which can simulate the neurological processing ability of the human brain. It was employed for building of the quantitative ...
The influence of inorganic salts with chaotropic properties on the chromatographic behavior of ropinirole and its two impurities
(Elsevier Science BV, Amsterdam, 2014)
Chaotropic agents recently gained popularity as interesting and useful mobile phase additives in liquid chromatography due to their effect on analytes retention, peak symmetry and separation efficiency. They mimic the role ...