Rationale for ibuprofen co-administration with antacids: Potential interaction mechanisms affecting drug absorption
Само за регистроване кориснике
2008
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Ibuprofen is a widely used NSAID which is often co-administered with antacids because of its gastro-irritant effects. Literature data suggest that antacid interactions may increase or decrease the drug's absorption rate and onset of action and that the interaction may be formulation specific. In the present study, literature data on ibuprofen absorption were evaluated in order to gain insight into the nature of the in vivo effect. Solubility determinations in reactive media containing magnesium or aluminium and dissolution studies in the presence of antacid suspension were performed in an attempt to simulate in vitro the effects observed in vivo. The results obtained indicate that magnesium hydroxide enhances ibuprofen solubility, dissolution and bioavailability, while aluminium hydroxide has a retarding effect. Solubility studies indicated formation of a soluble solid ibuprofen phase in the presence of Mg2+, in contrast, an insoluble ibuprofen salt was formed with Al3+. The introducti...on of magnesium based antacid suspension into the dissolution media resulted in a formulation specific increase in drug dissolution rate with the most pronounced effect observed for the slowest release tablet formulation. The results obtained indicate the potential for in vitro studies to predict physicochemical interactions that are likely to influence drug absorption rate in vivo.
Кључне речи:
ibuprofen-antacid interaction / absorption rate / solubility / dissolution / in vitro-in vivo correlationИзвор:
European Journal of Pharmaceutics and Biopharmaceutics, 2008, 69, 2, 640-647Издавач:
- Elsevier Science BV, Amsterdam
DOI: 10.1016/j.ejpb.2008.01.001
ISSN: 0939-6411
PubMed: 18595674
WoS: 000256710000026
Scopus: 2-s2.0-43349105478
Институција/група
PharmacyTY - JOUR AU - Parojčić, Jelena AU - Corrigan, Owen I. PY - 2008 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1076 AB - Ibuprofen is a widely used NSAID which is often co-administered with antacids because of its gastro-irritant effects. Literature data suggest that antacid interactions may increase or decrease the drug's absorption rate and onset of action and that the interaction may be formulation specific. In the present study, literature data on ibuprofen absorption were evaluated in order to gain insight into the nature of the in vivo effect. Solubility determinations in reactive media containing magnesium or aluminium and dissolution studies in the presence of antacid suspension were performed in an attempt to simulate in vitro the effects observed in vivo. The results obtained indicate that magnesium hydroxide enhances ibuprofen solubility, dissolution and bioavailability, while aluminium hydroxide has a retarding effect. Solubility studies indicated formation of a soluble solid ibuprofen phase in the presence of Mg2+, in contrast, an insoluble ibuprofen salt was formed with Al3+. The introduction of magnesium based antacid suspension into the dissolution media resulted in a formulation specific increase in drug dissolution rate with the most pronounced effect observed for the slowest release tablet formulation. The results obtained indicate the potential for in vitro studies to predict physicochemical interactions that are likely to influence drug absorption rate in vivo. PB - Elsevier Science BV, Amsterdam T2 - European Journal of Pharmaceutics and Biopharmaceutics T1 - Rationale for ibuprofen co-administration with antacids: Potential interaction mechanisms affecting drug absorption VL - 69 IS - 2 SP - 640 EP - 647 DO - 10.1016/j.ejpb.2008.01.001 ER -
@article{ author = "Parojčić, Jelena and Corrigan, Owen I.", year = "2008", abstract = "Ibuprofen is a widely used NSAID which is often co-administered with antacids because of its gastro-irritant effects. Literature data suggest that antacid interactions may increase or decrease the drug's absorption rate and onset of action and that the interaction may be formulation specific. In the present study, literature data on ibuprofen absorption were evaluated in order to gain insight into the nature of the in vivo effect. Solubility determinations in reactive media containing magnesium or aluminium and dissolution studies in the presence of antacid suspension were performed in an attempt to simulate in vitro the effects observed in vivo. The results obtained indicate that magnesium hydroxide enhances ibuprofen solubility, dissolution and bioavailability, while aluminium hydroxide has a retarding effect. Solubility studies indicated formation of a soluble solid ibuprofen phase in the presence of Mg2+, in contrast, an insoluble ibuprofen salt was formed with Al3+. The introduction of magnesium based antacid suspension into the dissolution media resulted in a formulation specific increase in drug dissolution rate with the most pronounced effect observed for the slowest release tablet formulation. The results obtained indicate the potential for in vitro studies to predict physicochemical interactions that are likely to influence drug absorption rate in vivo.", publisher = "Elsevier Science BV, Amsterdam", journal = "European Journal of Pharmaceutics and Biopharmaceutics", title = "Rationale for ibuprofen co-administration with antacids: Potential interaction mechanisms affecting drug absorption", volume = "69", number = "2", pages = "640-647", doi = "10.1016/j.ejpb.2008.01.001" }
Parojčić, J.,& Corrigan, O. I.. (2008). Rationale for ibuprofen co-administration with antacids: Potential interaction mechanisms affecting drug absorption. in European Journal of Pharmaceutics and Biopharmaceutics Elsevier Science BV, Amsterdam., 69(2), 640-647. https://doi.org/10.1016/j.ejpb.2008.01.001
Parojčić J, Corrigan OI. Rationale for ibuprofen co-administration with antacids: Potential interaction mechanisms affecting drug absorption. in European Journal of Pharmaceutics and Biopharmaceutics. 2008;69(2):640-647. doi:10.1016/j.ejpb.2008.01.001 .
Parojčić, Jelena, Corrigan, Owen I., "Rationale for ibuprofen co-administration with antacids: Potential interaction mechanisms affecting drug absorption" in European Journal of Pharmaceutics and Biopharmaceutics, 69, no. 2 (2008):640-647, https://doi.org/10.1016/j.ejpb.2008.01.001 . .