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dc.creatorSavić, Snežana
dc.creatorWeber, Christian
dc.creatorSavić, Miroslav
dc.creatorMueller-Goymann, Christel
dc.date.accessioned2019-09-02T11:17:00Z
dc.date.available2019-09-02T11:17:00Z
dc.date.issued2009
dc.identifier.issn0378-5173
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/1207
dc.description.abstractThis study focuses on the properties of topical vehicles based on alkylpolyglucoside natural surfactant-mixed emulsifier, cetearyl glucoside and cetearyl alcohol, in order to propose their use as "ready to use" pharmaceutical bases for a number of model drugs. We were interested to investigate how the alternative use of three lipophilic excipients (Ph. Eur. 6.0), differing in their polarity indexes (medium chain triglycerides (MG), decyl oleate (DO), and isopropyl myristate (IPM), respectively), affects the colloidal structure of the alkylpolyglucoside-based vehicles and in vitro permeation profiles of two model drugs: diclofenac sodium (DC) and caffeine (CF), both sparingly soluble in water. Finally, we aimed to evaluate the safety profile of such vehicles in vitro (acute skin irritation test using a cytotoxicity assay), comparing it with in vivo data obtained by the methods of skin bioengineering. The results have shown that the emulsion vehicles consisted of a complex colloidal structure of lamellar liquid crystalline and lamellar gel crystalline type. Varying of lipophilic excipient influenced noteworthy variations in the colloidal structure demonstrated as different theological profiles accompanied to the certain degree by different water distribution modes, but notably provoked by drug nature (an amphiphilic electrolyte drug vs. nonelectrolyte). In vitro permeation data obtained using ASC membranes in an infinite dose-type of experiment stressed the importance of the vehicle/solute interactions in case of small variation in formulation composition, asserting the drug properties in the first hours of permeation and theological profile of the vehicles in the later phase of experiment as decisive factors. In vitro skin irritation test demonstrated a mild nature of the emulsifying wax and the absence of negative effects of used oil phases on cell viability in formulation concentrations correspondent to the therapeutic need. This result alongside with data obtained from in vivo study, could additionally promote investigated topical vehicles as prospective "ready to use" pharmaceutical bases.en
dc.publisherElsevier Science BV, Amsterdam
dc.rightsrestrictedAccess
dc.sourceInternational Journal of Pharmaceutics
dc.subjectNatural surfactant-based topical vehiclesen
dc.subjectAlkylpolyglucosideen
dc.subjectMixed emulsifieren
dc.subjectMedium chain triglyceridesen
dc.subjectDecyl oleateen
dc.subjectIsopropyl myristateen
dc.subjectDiclofenac sodiumen
dc.subjectCaffeineen
dc.subjectIn vitro permeationen
dc.subjectCytotoxicity assayen
dc.subjectIn vivo skin performanceen
dc.titleNatural surfactant-based topical vehicles for two model drugs: Influence of different lipophilic excipients on in vitro/in vivo skin performanceen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractМуеллер-Гоyманн, Цхристел; Савић, Мирослав; Савић, Снежана; Wебер, Цхристиан;
dc.citation.volume381
dc.citation.issue2
dc.citation.spage220
dc.citation.epage230
dc.citation.other381(2): 220-230
dc.citation.rankM22
dc.identifier.wos000271336000019
dc.identifier.doi10.1016/j.ijpharm.2009.07.007
dc.identifier.pmid19616085
dc.identifier.scopus2-s2.0-70349400006
dc.identifier.rcubconv_2243
dc.type.versionpublishedVersion


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