Приказ основних података о документу

dc.creatorPorciatti, Elena
dc.creatorMilenković, Marina
dc.creatorGaggelli, Elena
dc.creatorValensin, Gianni
dc.creatorKozlowski, Henryk
dc.creatorKamysz, Wojciech
dc.creatorValensin, Daniela
dc.date.accessioned2019-09-02T11:20:01Z
dc.date.available2019-09-02T11:20:01Z
dc.date.issued2010
dc.identifier.issn0020-1669
dc.identifier.urihttps://farfar.pharmacy.bg.ac.rs/handle/123456789/1328
dc.description.abstractZinc binding to P113 (or demegen), a 12 amino acid (AKRHHGYKRKFH-NH2) fragment of histatin 5, was investigated by means of NMR and CD techniques, yielding delineation of the metal binding site and the 3D structure of the complex in water and in DMSO as well. The three His imidazole and the N-terminus nitrogens were found to act as the zinc coordinating atoms. A comparison with the previously reported Cu(II)-P113 complex disclosed that the two structures were rather diverse, in spite of an identical donor set. The two complexes were also tested for their antimicrobial activity in vitro against seven bacteria and two yeast strains: a minor activity of both complexes vs that of free ligand was given evidence, suggesting both metal ions may possibly play a negative role in vivo.en
dc.publisherAmer Chemical Soc, Washington
dc.relationCIRMMP (Consorzio Interuniversitario Risonanze Magnetiche di Metalloproteine Paramagnetiche)
dc.rightsrestrictedAccess
dc.sourceInorganic Chemistry
dc.titleStructural Characterization and Antimicrobial Activity of the Zn(II) Complex with P113 (Demegen), a Derivative of Histatin 5en
dc.typearticle
dc.rights.licenseARR
dcterms.abstractВаленсин, Даниела; Порциатти, Елена; Миленковић, Марина; Валенсин, Гианни; Козлоwски, Хенрyк; Гаггелли, Елена; Камyсз, Wојциецх;
dc.citation.volume49
dc.citation.issue19
dc.citation.spage8690
dc.citation.epage8698
dc.citation.other49(19): 8690-8698
dc.citation.rankM21
dc.identifier.wos000282084600011
dc.identifier.doi10.1021/ic902547t
dc.identifier.pmid20815365
dc.identifier.scopus2-s2.0-77957254923
dc.type.versionpublishedVersion


Документи

Thumbnail

Овај документ се појављује у следећим колекцијама

Приказ основних података о документу