Autoantibodies against human brain S-100 protein and neuron specific enolase in neurological and psychiatric patients
Апстракт
This report deals with the incidence and distribution of autoantibodies against well-defined human brain antigens S-100 and NSE in the development of neurologic and psychiatric syndromes. Serum samples from patients and controls were examined by means of an enzyme-linked immunosorbent assay (ELISA) for the presence of autoantibodies against human S-100 protein and NSE. The highest incidence of anti-S-100 and anti-NSE antibodies was in Parkinson's disease, Alzheimer's disease and senile dementia, and the lowest in schizophrenia and alcoholic syndrome. The frequency of anti-S-100 autoantibodies was higher than that of anti-NSE. In healthy individuals the incidence of antibrain antibodies was low. These results suggest the involvement of human autoimmune mechanism in the development of certain neuropsychiatric diseases.
Извор:
Jugoslovenska medicinska biohemija, 1997, 16, 4, 217-219Издавач:
- Društvo medicinskih biohemičara Srbije i Crne Gore, Beograd i Univerzitet u Beogradu - Farmaceutski fakultet, Beograd
Институција/група
PharmacyTY - JOUR AU - Horvat, J AU - Begović, D AU - Stojić-Vukanić, Zorica AU - Milošević, D PY - 1997 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/145 AB - This report deals with the incidence and distribution of autoantibodies against well-defined human brain antigens S-100 and NSE in the development of neurologic and psychiatric syndromes. Serum samples from patients and controls were examined by means of an enzyme-linked immunosorbent assay (ELISA) for the presence of autoantibodies against human S-100 protein and NSE. The highest incidence of anti-S-100 and anti-NSE antibodies was in Parkinson's disease, Alzheimer's disease and senile dementia, and the lowest in schizophrenia and alcoholic syndrome. The frequency of anti-S-100 autoantibodies was higher than that of anti-NSE. In healthy individuals the incidence of antibrain antibodies was low. These results suggest the involvement of human autoimmune mechanism in the development of certain neuropsychiatric diseases. PB - Društvo medicinskih biohemičara Srbije i Crne Gore, Beograd i Univerzitet u Beogradu - Farmaceutski fakultet, Beograd T2 - Jugoslovenska medicinska biohemija T1 - Autoantibodies against human brain S-100 protein and neuron specific enolase in neurological and psychiatric patients VL - 16 IS - 4 SP - 217 EP - 219 UR - https://hdl.handle.net/21.15107/rcub_farfar_145 ER -
@article{ author = "Horvat, J and Begović, D and Stojić-Vukanić, Zorica and Milošević, D", year = "1997", abstract = "This report deals with the incidence and distribution of autoantibodies against well-defined human brain antigens S-100 and NSE in the development of neurologic and psychiatric syndromes. Serum samples from patients and controls were examined by means of an enzyme-linked immunosorbent assay (ELISA) for the presence of autoantibodies against human S-100 protein and NSE. The highest incidence of anti-S-100 and anti-NSE antibodies was in Parkinson's disease, Alzheimer's disease and senile dementia, and the lowest in schizophrenia and alcoholic syndrome. The frequency of anti-S-100 autoantibodies was higher than that of anti-NSE. In healthy individuals the incidence of antibrain antibodies was low. These results suggest the involvement of human autoimmune mechanism in the development of certain neuropsychiatric diseases.", publisher = "Društvo medicinskih biohemičara Srbije i Crne Gore, Beograd i Univerzitet u Beogradu - Farmaceutski fakultet, Beograd", journal = "Jugoslovenska medicinska biohemija", title = "Autoantibodies against human brain S-100 protein and neuron specific enolase in neurological and psychiatric patients", volume = "16", number = "4", pages = "217-219", url = "https://hdl.handle.net/21.15107/rcub_farfar_145" }
Horvat, J., Begović, D., Stojić-Vukanić, Z.,& Milošević, D.. (1997). Autoantibodies against human brain S-100 protein and neuron specific enolase in neurological and psychiatric patients. in Jugoslovenska medicinska biohemija Društvo medicinskih biohemičara Srbije i Crne Gore, Beograd i Univerzitet u Beogradu - Farmaceutski fakultet, Beograd., 16(4), 217-219. https://hdl.handle.net/21.15107/rcub_farfar_145
Horvat J, Begović D, Stojić-Vukanić Z, Milošević D. Autoantibodies against human brain S-100 protein and neuron specific enolase in neurological and psychiatric patients. in Jugoslovenska medicinska biohemija. 1997;16(4):217-219. https://hdl.handle.net/21.15107/rcub_farfar_145 .
Horvat, J, Begović, D, Stojić-Vukanić, Zorica, Milošević, D, "Autoantibodies against human brain S-100 protein and neuron specific enolase in neurological and psychiatric patients" in Jugoslovenska medicinska biohemija, 16, no. 4 (1997):217-219, https://hdl.handle.net/21.15107/rcub_farfar_145 .