Evaluation of Single-Point Sampling Strategies for the Estimation of Moclobemide Exposure in Depressive Patients
Само за регистроване кориснике
2011
Аутори
Rakić-Ignjatović, AnitaMiljković, Branislava
Todorović, Dejan
Timotijević, Ivana
Pokrajac, Milena
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Because moclobemide pharmacokinetics vary considerably among individuals, monitoring of plasma concentrations lends insight into its pharmacokinetic behavior and enhances its rational use in clinical practice. The aim of this study was to evaluate whether single concentration-time points could adequately predict moclobemide systemic exposure. Pharmacokinetic data (full 7-point pharmacokinetic profiles), obtained from 21 depressive inpatients receiving moclobemide (150 mg 3 times daily), were randomly split into development (n = 18) and validation (n = 16) sets. Correlations between the single concentration-time points and the area under the concentration-time curve within a 6-hour dosing interval at steady-state (AUC(0-6)) were assessed by linear regression analyses. The predictive performance of single-point sampling strategies was evaluated in the validation set by mean prediction error, mean absolute error, and root mean square error. Plasma concentrations in the absorption phase yi...elded unsatisfactory predictions of moclobemide AUC(0-6). The best estimation of AUC(0-6) was achieved from concentrations at 4 and 6 hours following dosing. As the most reliable surrogate for moclobemide systemic exposure, concentrations at 4 and 6 hours should be used instead of predose trough concentrations as an indicator of between-patient variability and a guide for dose adjustments in specific clinical situations.
Кључне речи:
Moclobemide / single-point sampling strategies / systemic exposure / predictive performance / depressive patientsИзвор:
Journal of Clinical Pharmacology, 2011, 51, 5, 661-671Издавач:
- Wiley, Hoboken
Финансирање / пројекти:
- Експериментална и клиничко-фармаколошка истраживања механизма дејства и интеракција лекова у нервном и кардиоваскуларном систему (RS-MESTD-MPN2006-2010-145001)
DOI: 10.1177/0091270010372105
ISSN: 0091-2700
PubMed: 20495135
WoS: 000289942400005
Scopus: 2-s2.0-79955541937
Институција/група
PharmacyTY - JOUR AU - Rakić-Ignjatović, Anita AU - Miljković, Branislava AU - Todorović, Dejan AU - Timotijević, Ivana AU - Pokrajac, Milena PY - 2011 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1518 AB - Because moclobemide pharmacokinetics vary considerably among individuals, monitoring of plasma concentrations lends insight into its pharmacokinetic behavior and enhances its rational use in clinical practice. The aim of this study was to evaluate whether single concentration-time points could adequately predict moclobemide systemic exposure. Pharmacokinetic data (full 7-point pharmacokinetic profiles), obtained from 21 depressive inpatients receiving moclobemide (150 mg 3 times daily), were randomly split into development (n = 18) and validation (n = 16) sets. Correlations between the single concentration-time points and the area under the concentration-time curve within a 6-hour dosing interval at steady-state (AUC(0-6)) were assessed by linear regression analyses. The predictive performance of single-point sampling strategies was evaluated in the validation set by mean prediction error, mean absolute error, and root mean square error. Plasma concentrations in the absorption phase yielded unsatisfactory predictions of moclobemide AUC(0-6). The best estimation of AUC(0-6) was achieved from concentrations at 4 and 6 hours following dosing. As the most reliable surrogate for moclobemide systemic exposure, concentrations at 4 and 6 hours should be used instead of predose trough concentrations as an indicator of between-patient variability and a guide for dose adjustments in specific clinical situations. PB - Wiley, Hoboken T2 - Journal of Clinical Pharmacology T1 - Evaluation of Single-Point Sampling Strategies for the Estimation of Moclobemide Exposure in Depressive Patients VL - 51 IS - 5 SP - 661 EP - 671 DO - 10.1177/0091270010372105 ER -
@article{ author = "Rakić-Ignjatović, Anita and Miljković, Branislava and Todorović, Dejan and Timotijević, Ivana and Pokrajac, Milena", year = "2011", abstract = "Because moclobemide pharmacokinetics vary considerably among individuals, monitoring of plasma concentrations lends insight into its pharmacokinetic behavior and enhances its rational use in clinical practice. The aim of this study was to evaluate whether single concentration-time points could adequately predict moclobemide systemic exposure. Pharmacokinetic data (full 7-point pharmacokinetic profiles), obtained from 21 depressive inpatients receiving moclobemide (150 mg 3 times daily), were randomly split into development (n = 18) and validation (n = 16) sets. Correlations between the single concentration-time points and the area under the concentration-time curve within a 6-hour dosing interval at steady-state (AUC(0-6)) were assessed by linear regression analyses. The predictive performance of single-point sampling strategies was evaluated in the validation set by mean prediction error, mean absolute error, and root mean square error. Plasma concentrations in the absorption phase yielded unsatisfactory predictions of moclobemide AUC(0-6). The best estimation of AUC(0-6) was achieved from concentrations at 4 and 6 hours following dosing. As the most reliable surrogate for moclobemide systemic exposure, concentrations at 4 and 6 hours should be used instead of predose trough concentrations as an indicator of between-patient variability and a guide for dose adjustments in specific clinical situations.", publisher = "Wiley, Hoboken", journal = "Journal of Clinical Pharmacology", title = "Evaluation of Single-Point Sampling Strategies for the Estimation of Moclobemide Exposure in Depressive Patients", volume = "51", number = "5", pages = "661-671", doi = "10.1177/0091270010372105" }
Rakić-Ignjatović, A., Miljković, B., Todorović, D., Timotijević, I.,& Pokrajac, M.. (2011). Evaluation of Single-Point Sampling Strategies for the Estimation of Moclobemide Exposure in Depressive Patients. in Journal of Clinical Pharmacology Wiley, Hoboken., 51(5), 661-671. https://doi.org/10.1177/0091270010372105
Rakić-Ignjatović A, Miljković B, Todorović D, Timotijević I, Pokrajac M. Evaluation of Single-Point Sampling Strategies for the Estimation of Moclobemide Exposure in Depressive Patients. in Journal of Clinical Pharmacology. 2011;51(5):661-671. doi:10.1177/0091270010372105 .
Rakić-Ignjatović, Anita, Miljković, Branislava, Todorović, Dejan, Timotijević, Ivana, Pokrajac, Milena, "Evaluation of Single-Point Sampling Strategies for the Estimation of Moclobemide Exposure in Depressive Patients" in Journal of Clinical Pharmacology, 51, no. 5 (2011):661-671, https://doi.org/10.1177/0091270010372105 . .