Comparative Study of Spasmolytic Properties, Antioxidant Activity and Phenolic Content of Arbutus unedo from Montenegro and Greece
Abstract
Arbutus unedo leaf is used traditionally for gastrointestinal complaints. Ethanol extracts from Arbutus unedo collected in both Montenegro (AuM) and Greece (AuG) were found to decrease the ileal basal tonus, with AuG producing a significantly higher (p lt 0.05) reduction in contractile response to acetylcholine. AuM and AuG relaxed 80 mM K(+) induced contractions and shifted the Ca concentration-response curves to the right, similar to that caused by verapamil, suggesting that the spasmolytic effect was induced through calcium channel inhibition. The antioxidant activity of AuM and AuG and the phenolic content of the extracts and dry plant material were studied, and both extracts were found to possess considerable antioxidant properties. AuG showed a stronger in vitro antioxidative activity in the DPPH assay and in the TBA test. Polyphenol, tannin and flavonoid levels were higher in AuG, supporting the more potent spasmolytic and antioxidative effects, whereas the arbutin content was... higher in dry plant material collected in Montenegro. Copyright
Keywords:
Arbutus unedo / spasmolytic / rat ileum / antioxidant / polyphenol / arbutinSource:
Phytotherapy Research, 2011, 25, 5, 749-754Publisher:
- Wiley-Blackwell, Malden
Funding / projects:
DOI: 10.1002/ptr.3460
ISSN: 0951-418X
PubMed: 21438047
WoS: 000289999400018
Scopus: 2-s2.0-79955533659
Collections
Institution/Community
PharmacyTY - JOUR AU - Pavlović, Dragana R. AU - Branković, Suzana AU - Kovačević, Nada AU - Kitić, Dušanka AU - Veljković, Slavimir PY - 2011 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1574 AB - Arbutus unedo leaf is used traditionally for gastrointestinal complaints. Ethanol extracts from Arbutus unedo collected in both Montenegro (AuM) and Greece (AuG) were found to decrease the ileal basal tonus, with AuG producing a significantly higher (p lt 0.05) reduction in contractile response to acetylcholine. AuM and AuG relaxed 80 mM K(+) induced contractions and shifted the Ca concentration-response curves to the right, similar to that caused by verapamil, suggesting that the spasmolytic effect was induced through calcium channel inhibition. The antioxidant activity of AuM and AuG and the phenolic content of the extracts and dry plant material were studied, and both extracts were found to possess considerable antioxidant properties. AuG showed a stronger in vitro antioxidative activity in the DPPH assay and in the TBA test. Polyphenol, tannin and flavonoid levels were higher in AuG, supporting the more potent spasmolytic and antioxidative effects, whereas the arbutin content was higher in dry plant material collected in Montenegro. Copyright PB - Wiley-Blackwell, Malden T2 - Phytotherapy Research T1 - Comparative Study of Spasmolytic Properties, Antioxidant Activity and Phenolic Content of Arbutus unedo from Montenegro and Greece VL - 25 IS - 5 SP - 749 EP - 754 DO - 10.1002/ptr.3460 ER -
@article{ author = "Pavlović, Dragana R. and Branković, Suzana and Kovačević, Nada and Kitić, Dušanka and Veljković, Slavimir", year = "2011", abstract = "Arbutus unedo leaf is used traditionally for gastrointestinal complaints. Ethanol extracts from Arbutus unedo collected in both Montenegro (AuM) and Greece (AuG) were found to decrease the ileal basal tonus, with AuG producing a significantly higher (p lt 0.05) reduction in contractile response to acetylcholine. AuM and AuG relaxed 80 mM K(+) induced contractions and shifted the Ca concentration-response curves to the right, similar to that caused by verapamil, suggesting that the spasmolytic effect was induced through calcium channel inhibition. The antioxidant activity of AuM and AuG and the phenolic content of the extracts and dry plant material were studied, and both extracts were found to possess considerable antioxidant properties. AuG showed a stronger in vitro antioxidative activity in the DPPH assay and in the TBA test. Polyphenol, tannin and flavonoid levels were higher in AuG, supporting the more potent spasmolytic and antioxidative effects, whereas the arbutin content was higher in dry plant material collected in Montenegro. Copyright", publisher = "Wiley-Blackwell, Malden", journal = "Phytotherapy Research", title = "Comparative Study of Spasmolytic Properties, Antioxidant Activity and Phenolic Content of Arbutus unedo from Montenegro and Greece", volume = "25", number = "5", pages = "749-754", doi = "10.1002/ptr.3460" }
Pavlović, D. R., Branković, S., Kovačević, N., Kitić, D.,& Veljković, S.. (2011). Comparative Study of Spasmolytic Properties, Antioxidant Activity and Phenolic Content of Arbutus unedo from Montenegro and Greece. in Phytotherapy Research Wiley-Blackwell, Malden., 25(5), 749-754. https://doi.org/10.1002/ptr.3460
Pavlović DR, Branković S, Kovačević N, Kitić D, Veljković S. Comparative Study of Spasmolytic Properties, Antioxidant Activity and Phenolic Content of Arbutus unedo from Montenegro and Greece. in Phytotherapy Research. 2011;25(5):749-754. doi:10.1002/ptr.3460 .
Pavlović, Dragana R., Branković, Suzana, Kovačević, Nada, Kitić, Dušanka, Veljković, Slavimir, "Comparative Study of Spasmolytic Properties, Antioxidant Activity and Phenolic Content of Arbutus unedo from Montenegro and Greece" in Phytotherapy Research, 25, no. 5 (2011):749-754, https://doi.org/10.1002/ptr.3460 . .