Effect of fillers and lubricants on acetylsalicylic acid release kinetics from Eudragit matrix tablets
Само за регистроване кориснике
1997
Аутори
Jovanović, MJovicić, G
Đurić, Zorica
Agbaba, Danica
Karljiković-Rajić, Katarina
Radovanović, J
Nikolić, L
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
The effect of fillers and lubricants on the dissolution rate of acetylsalicylic acid (ASA) from matrix tablets has been evaluated. Eudragit S-100 and Eudragit L-100-55 where chosen as matrix substances. The process of drug release in vitro was studied by the modified half-change method. The dissolution data were evaluated on the basis of theoretical dissolution equations and by linear transformation of dissolution curves. Differences in release rate of ASA from matrix tablets, regarding the diluents used, appeared to be more significant when matrices contained Eudragit L-100-55 as compared to Eudragit S-100. The highest dissolution rates of ASA were observed in the presence of Lubritab as lubricant. The other lubricants used showed similar effects on the release rate of ASA. The release of ASA from samples containing Eudragit L-100-55 corresponded best to the zero-order kinetics. The best-fitted model for the ASA release from tablets prepared with Eudragit S-100 was obtained by using t...he Hixson-Crowell equation.
Извор:
Drug Development and Industrial Pharmacy, 1997, 23, 6, 595-602Издавач:
- Marcel Dekker Inc, New York
DOI: 10.3109/03639049709149825
ISSN: 0363-9045
WoS: A1997WW01100012
Scopus: 2-s2.0-0343488734
Институција/група
PharmacyTY - JOUR AU - Jovanović, M AU - Jovicić, G AU - Đurić, Zorica AU - Agbaba, Danica AU - Karljiković-Rajić, Katarina AU - Radovanović, J AU - Nikolić, L PY - 1997 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/161 AB - The effect of fillers and lubricants on the dissolution rate of acetylsalicylic acid (ASA) from matrix tablets has been evaluated. Eudragit S-100 and Eudragit L-100-55 where chosen as matrix substances. The process of drug release in vitro was studied by the modified half-change method. The dissolution data were evaluated on the basis of theoretical dissolution equations and by linear transformation of dissolution curves. Differences in release rate of ASA from matrix tablets, regarding the diluents used, appeared to be more significant when matrices contained Eudragit L-100-55 as compared to Eudragit S-100. The highest dissolution rates of ASA were observed in the presence of Lubritab as lubricant. The other lubricants used showed similar effects on the release rate of ASA. The release of ASA from samples containing Eudragit L-100-55 corresponded best to the zero-order kinetics. The best-fitted model for the ASA release from tablets prepared with Eudragit S-100 was obtained by using the Hixson-Crowell equation. PB - Marcel Dekker Inc, New York T2 - Drug Development and Industrial Pharmacy T1 - Effect of fillers and lubricants on acetylsalicylic acid release kinetics from Eudragit matrix tablets VL - 23 IS - 6 SP - 595 EP - 602 DO - 10.3109/03639049709149825 ER -
@article{ author = "Jovanović, M and Jovicić, G and Đurić, Zorica and Agbaba, Danica and Karljiković-Rajić, Katarina and Radovanović, J and Nikolić, L", year = "1997", abstract = "The effect of fillers and lubricants on the dissolution rate of acetylsalicylic acid (ASA) from matrix tablets has been evaluated. Eudragit S-100 and Eudragit L-100-55 where chosen as matrix substances. The process of drug release in vitro was studied by the modified half-change method. The dissolution data were evaluated on the basis of theoretical dissolution equations and by linear transformation of dissolution curves. Differences in release rate of ASA from matrix tablets, regarding the diluents used, appeared to be more significant when matrices contained Eudragit L-100-55 as compared to Eudragit S-100. The highest dissolution rates of ASA were observed in the presence of Lubritab as lubricant. The other lubricants used showed similar effects on the release rate of ASA. The release of ASA from samples containing Eudragit L-100-55 corresponded best to the zero-order kinetics. The best-fitted model for the ASA release from tablets prepared with Eudragit S-100 was obtained by using the Hixson-Crowell equation.", publisher = "Marcel Dekker Inc, New York", journal = "Drug Development and Industrial Pharmacy", title = "Effect of fillers and lubricants on acetylsalicylic acid release kinetics from Eudragit matrix tablets", volume = "23", number = "6", pages = "595-602", doi = "10.3109/03639049709149825" }
Jovanović, M., Jovicić, G., Đurić, Z., Agbaba, D., Karljiković-Rajić, K., Radovanović, J.,& Nikolić, L.. (1997). Effect of fillers and lubricants on acetylsalicylic acid release kinetics from Eudragit matrix tablets. in Drug Development and Industrial Pharmacy Marcel Dekker Inc, New York., 23(6), 595-602. https://doi.org/10.3109/03639049709149825
Jovanović M, Jovicić G, Đurić Z, Agbaba D, Karljiković-Rajić K, Radovanović J, Nikolić L. Effect of fillers and lubricants on acetylsalicylic acid release kinetics from Eudragit matrix tablets. in Drug Development and Industrial Pharmacy. 1997;23(6):595-602. doi:10.3109/03639049709149825 .
Jovanović, M, Jovicić, G, Đurić, Zorica, Agbaba, Danica, Karljiković-Rajić, Katarina, Radovanović, J, Nikolić, L, "Effect of fillers and lubricants on acetylsalicylic acid release kinetics from Eudragit matrix tablets" in Drug Development and Industrial Pharmacy, 23, no. 6 (1997):595-602, https://doi.org/10.3109/03639049709149825 . .