Binuclear biologically active Co(II) complexes with octazamacrocycle and aliphatic dicarboxylates
Samo za registrovane korisnike
2012
Autori
Tanasković, SlađanaVucković, Gordana
Antonijević-Nikolić, Mirjana
Stanojković, Tatjana
Gojgić-Cvijović, Gordana
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
Four new cationic Co(II) complexes with N,N',N '',N'''-tetrakis (2-pyridylmethyl)-1,4,8,11-tetraazacyclotetradecane (tpmc) and dianion of one the aliphatic dicarboxylic acids: butanedioic acid (succinic) acid = succH(2), pentanedioic (glutaric) acid = gluH(2), hexanedioic acid (adipic) acid = adipH(2) or decanedioic acid (sebacic) acid = sebH(2) of general formula [Co-2(L)(tpmc)](ClO4)(2)center dot xY, L2- = succ, x = 1, Y = H2O; L = glu, x = 1, Y = H2O; L = adip, x = 1.5, Y = H2O; L = seb, x = 1, Y = CH3CN were isolated. The composition and charge are proposed based on elemental analyses (C, H. N) and electrical conductivity measurements. UV-Vis and FTIR spectral data and magnetic moments were in accordance with high-spin Co(II) state. It is proposed that in all complexes Co(II) is hexa-coordinated out of cyclam ring and that both carboxylic groups from dicarboxylate bridge participate in coordination. Oxygens from one group are most likely bonded to the same Co(II) ion thus forming a... four-membered ring. The in vitro antibacterial/antiproliferative activities of the complexes were in some cases enhanced compared with the simple Co(II) salt and free ligands, tested as controls.
Ključne reči:
Cobalt(II) complexes / Octazamacrocycle / alpha,omega-Dicarboxylates / Antibacterial / Antiproliferative assayIzvor:
Journal of Molecular Structure, 2012, 1029, 1-7Izdavač:
- Elsevier Science BV, Amsterdam
Finansiranje / projekti:
- Dizajniranje, sinteza, karakterizacija i procena praktične primene koordinacionih i organometalnih jedinjenja (RS-MESTD-Basic Research (BR or ON)-172014)
DOI: 10.1016/j.molstruc.2012.06.055
ISSN: 0022-2860
WoS: 000312176800001
Scopus: 2-s2.0-84865329142
Institucija/grupa
PharmacyTY - JOUR AU - Tanasković, Slađana AU - Vucković, Gordana AU - Antonijević-Nikolić, Mirjana AU - Stanojković, Tatjana AU - Gojgić-Cvijović, Gordana PY - 2012 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1674 AB - Four new cationic Co(II) complexes with N,N',N '',N'''-tetrakis (2-pyridylmethyl)-1,4,8,11-tetraazacyclotetradecane (tpmc) and dianion of one the aliphatic dicarboxylic acids: butanedioic acid (succinic) acid = succH(2), pentanedioic (glutaric) acid = gluH(2), hexanedioic acid (adipic) acid = adipH(2) or decanedioic acid (sebacic) acid = sebH(2) of general formula [Co-2(L)(tpmc)](ClO4)(2)center dot xY, L2- = succ, x = 1, Y = H2O; L = glu, x = 1, Y = H2O; L = adip, x = 1.5, Y = H2O; L = seb, x = 1, Y = CH3CN were isolated. The composition and charge are proposed based on elemental analyses (C, H. N) and electrical conductivity measurements. UV-Vis and FTIR spectral data and magnetic moments were in accordance with high-spin Co(II) state. It is proposed that in all complexes Co(II) is hexa-coordinated out of cyclam ring and that both carboxylic groups from dicarboxylate bridge participate in coordination. Oxygens from one group are most likely bonded to the same Co(II) ion thus forming a four-membered ring. The in vitro antibacterial/antiproliferative activities of the complexes were in some cases enhanced compared with the simple Co(II) salt and free ligands, tested as controls. PB - Elsevier Science BV, Amsterdam T2 - Journal of Molecular Structure T1 - Binuclear biologically active Co(II) complexes with octazamacrocycle and aliphatic dicarboxylates VL - 1029 SP - 1 EP - 7 DO - 10.1016/j.molstruc.2012.06.055 ER -
@article{ author = "Tanasković, Slađana and Vucković, Gordana and Antonijević-Nikolić, Mirjana and Stanojković, Tatjana and Gojgić-Cvijović, Gordana", year = "2012", abstract = "Four new cationic Co(II) complexes with N,N',N '',N'''-tetrakis (2-pyridylmethyl)-1,4,8,11-tetraazacyclotetradecane (tpmc) and dianion of one the aliphatic dicarboxylic acids: butanedioic acid (succinic) acid = succH(2), pentanedioic (glutaric) acid = gluH(2), hexanedioic acid (adipic) acid = adipH(2) or decanedioic acid (sebacic) acid = sebH(2) of general formula [Co-2(L)(tpmc)](ClO4)(2)center dot xY, L2- = succ, x = 1, Y = H2O; L = glu, x = 1, Y = H2O; L = adip, x = 1.5, Y = H2O; L = seb, x = 1, Y = CH3CN were isolated. The composition and charge are proposed based on elemental analyses (C, H. N) and electrical conductivity measurements. UV-Vis and FTIR spectral data and magnetic moments were in accordance with high-spin Co(II) state. It is proposed that in all complexes Co(II) is hexa-coordinated out of cyclam ring and that both carboxylic groups from dicarboxylate bridge participate in coordination. Oxygens from one group are most likely bonded to the same Co(II) ion thus forming a four-membered ring. The in vitro antibacterial/antiproliferative activities of the complexes were in some cases enhanced compared with the simple Co(II) salt and free ligands, tested as controls.", publisher = "Elsevier Science BV, Amsterdam", journal = "Journal of Molecular Structure", title = "Binuclear biologically active Co(II) complexes with octazamacrocycle and aliphatic dicarboxylates", volume = "1029", pages = "1-7", doi = "10.1016/j.molstruc.2012.06.055" }
Tanasković, S., Vucković, G., Antonijević-Nikolić, M., Stanojković, T.,& Gojgić-Cvijović, G.. (2012). Binuclear biologically active Co(II) complexes with octazamacrocycle and aliphatic dicarboxylates. in Journal of Molecular Structure Elsevier Science BV, Amsterdam., 1029, 1-7. https://doi.org/10.1016/j.molstruc.2012.06.055
Tanasković S, Vucković G, Antonijević-Nikolić M, Stanojković T, Gojgić-Cvijović G. Binuclear biologically active Co(II) complexes with octazamacrocycle and aliphatic dicarboxylates. in Journal of Molecular Structure. 2012;1029:1-7. doi:10.1016/j.molstruc.2012.06.055 .
Tanasković, Slađana, Vucković, Gordana, Antonijević-Nikolić, Mirjana, Stanojković, Tatjana, Gojgić-Cvijović, Gordana, "Binuclear biologically active Co(II) complexes with octazamacrocycle and aliphatic dicarboxylates" in Journal of Molecular Structure, 1029 (2012):1-7, https://doi.org/10.1016/j.molstruc.2012.06.055 . .