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Composition, antimicrobial, antiradical and spasmolytic activity of Ferula heuffelii Griseb. ex Heuffel (Apiaceae) essential oil
dc.creator | Pavlović, Ivan | |
dc.creator | Petrović, Silvana | |
dc.creator | Radenković, Mirjana | |
dc.creator | Milenković, Marina | |
dc.creator | Couladis, Maria | |
dc.creator | Branković, Suzana | |
dc.creator | Drobac, Milica | |
dc.creator | Niketić, Marjan | |
dc.date.accessioned | 2019-09-02T11:29:17Z | |
dc.date.available | 2019-09-02T11:29:17Z | |
dc.date.issued | 2012 | |
dc.identifier.issn | 0308-8146 | |
dc.identifier.uri | https://farfar.pharmacy.bg.ac.rs/handle/123456789/1715 | |
dc.description.abstract | The essential oil from underground parts of Ferula heuffelii from N.E. Serbia, was analysed using GC and GC-MS. The main compounds of the essential oil were elemicin (35.4%) and myristicin (20.6%). The essential oil exhibited the best antimicrobial activity against two strains of Candida albicans (MIC = 7.0 and 13.7 mu g/ml), as well as against Micrococcus luteus (MIC = 13.7 mu g/ml), Staphylococcus epidermidis (MIC = 17.6 mu g/ml), Bacillus subtilis (MIC = 21.1 mu g/ml) and Micrococcus flavus (MIC = 28.2 mu g/ml). In the DPPH radical scavenging assay, essential oil showed substantial activity with SC(50) = 22.43 mu l/ml. The essential oil was also tested for antispasmodic activity. It inhibited spontaneous contraction of isolated rat ileum dose-dependently, and at the concentration of 86.64 mu g/ml exhibited 50% of the maximum effect of atropine. After incubation with 75.00 mu g/ml of essential oil, acetylcholine did not induce contractions of ileum, and at 250.00 mu g/ml, the essential oil almost completely abolished the spasmodic effect of potassium chloride (80 mM). | en |
dc.publisher | Elsevier Sci Ltd, Oxford | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173021/RS// | |
dc.rights | restrictedAccess | |
dc.source | Food Chemistry | |
dc.subject | Ferula heuffelii | en |
dc.subject | Essential oil composition | en |
dc.subject | Antimicrobial activity | en |
dc.subject | Antiradical activity | en |
dc.subject | Antispasmodic activity | en |
dc.title | Composition, antimicrobial, antiradical and spasmolytic activity of Ferula heuffelii Griseb. ex Heuffel (Apiaceae) essential oil | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Дробац, Милица; Цоуладис, Мариа; Бранковић, Сузана; Никетић, Марјан; Раденковић, Мирјана; Павловић, Иван; Миленковић, Марина; Петровић, Силвана; | |
dc.citation.volume | 130 | |
dc.citation.issue | 2 | |
dc.citation.spage | 310 | |
dc.citation.epage | 315 | |
dc.citation.other | 130(2): 310-315 | |
dc.citation.rank | aM21 | |
dc.identifier.wos | 000296267400013 | |
dc.identifier.doi | 10.1016/j.foodchem.2011.07.043 | |
dc.identifier.scopus | 2-s2.0-80052273360 | |
dc.type.version | publishedVersion |