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TLC determination of glimepiride and its main impurities in pharmaceuticals
dc.creator | Topić, Valentina | |
dc.creator | Filipić, Slavica | |
dc.creator | Popović, Gordana | |
dc.creator | Nikolić, Katarina | |
dc.creator | Agbaba, Danica | |
dc.date.accessioned | 2019-09-02T11:35:35Z | |
dc.date.available | 2019-09-02T11:35:35Z | |
dc.date.issued | 2013 | |
dc.identifier.issn | 1082-6076 | |
dc.identifier.uri | https://farfar.pharmacy.bg.ac.rs/handle/123456789/1968 | |
dc.description.abstract | A quantitative TLC method was developed for the simultaneous separation and quantification of glimepiride and its main degradation impurities, glimepiride-sulfonamide, and glimepiride-carbamate. Chromatographic analysis was performed using the commercial aluminum-backed TLC plates precoated with silica gel 60F(254) as stationary phase and toluene-ethyl acetate-methanol 8:5:1 (v/v) as the mobile phase. Detection was performed at 230nm. Regression coefficients (r>0.997), recovery (94.9 to 105.1%), determination limit of impurities (7ng spot(-1) equivalent to the 0.1% impurity level), and robustness were validated and found to be satisfactory. The method is convenient for quantitative analysis and purity control of glimepiride in its dosage forms. | en |
dc.publisher | Taylor & Francis Inc, Philadelphia | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172033/RS// | |
dc.rights | restrictedAccess | |
dc.source | Journal of Liquid Chromatography & Related Technologies | |
dc.subject | glimepiride | en |
dc.subject | hypoglycemic drug | en |
dc.subject | impurities | en |
dc.subject | pharmaceutical dosage forms | en |
dc.subject | quantification | en |
dc.subject | TLC | en |
dc.title | TLC determination of glimepiride and its main impurities in pharmaceuticals | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Aгбаба, Даница; Топић, Валентина; Филипић, Славица; Николић, Катарина; Поповић, Гордана; | |
dc.citation.volume | 36 | |
dc.citation.issue | 17 | |
dc.citation.spage | 2422 | |
dc.citation.epage | 2430 | |
dc.citation.other | 36(17): 2422-2430 | |
dc.citation.rank | M23 | |
dc.description.other | Peer-reviewed manuscript: [http://farfar.pharmacy.bg.ac.rs/handle/123456789/3435] | |
dc.identifier.wos | 000321812900008 | |
dc.identifier.doi | 10.1080/10826076.2013.790767 | |
dc.identifier.scopus | 2-s2.0-84880376950 | |
dc.type.version | publishedVersion |
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