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Oral treatment with Lactobacillus rhamnosus 64 during the early postnatal period improves the health of adult rats with TNBS-induced colitis
(Elsevier Science BV, Amsterdam, 2018)
The current study investigated a potential modulating effect of orally applied Lactobacillus rhamnosus 64 (LB64) during the early postnatal period (day of life: similar to 3-30), during young adult period (day of life: ...
The influence of aging and estradiol to progesterone ratio on rat macrophage phenotypic profile and NO and TNF-alpha production
(Pergamon-Elsevier Science Ltd, Oxford, 2013)
The phenotype and function of tissue macrophages substantially depend on the cellular milieu and biological effector molecules, such as steroid hormones, to which they are exposed. Furthermore, in female rats, aging is ...
Quality by Design oriented development of hydrophilic interaction liquid chromatography method for the analysis of amitriptyline and its impurities
(Elsevier Science BV, Amsterdam, 2019)
This paper presents integration of Quality by Design concept in the development of hydrophilic interactions liquid chromatographic methods for analysis of amitriptyline and its impurities (A, B, C, and F). This is the first ...
Development and Optimization of an HPLC Analysis of Citalopram and Its Four Nonchiral Impurities Using Experimental Design Methodology
(AOAC Int, Gaithersburg, 2012)
In this study, the RP-HPLC method was investigated for the separation of citalopram and its four impurities by use of statistical experimental design. Initially, the influence of different experimental conditions (buffer ...
Route-dependent effects of cadmium/cadmium and magnesium acute treatment on parameters of oxidative stress in rat liver
(Pergamon-Elsevier Science Ltd, Oxford, 2012)
The study was designed to evaluate and compare the effects of single oral (or) and intraperitoneal (i.p.) cadmium (Cd) administration on parameters of oxidative stress in liver of rats. Furthermore, investigation on ...
Chromatographic Analysis of Olopatadine in Hydrophilic Interaction Liquid Chromatography
(Oxford Univ Press Inc, Cary, 2015)
In this paper, chromatographic analysis of active substance olopatadine hydrochloride, which is used in eye drops as antihistaminic agent, and its impurity E isomer by hydrophilic interaction liquid chromatography (HILIC) ...
Tolerance liability of diazepam is dependent on the dose used for protracted treatment
(Polish Acad Sciences Inst Pharmacology, Krakow, 2012)
Background: Behavioral effects of benzodiazepines following repeated exposure vary according to the intrinsic efficacy of the benzodiazepine studied, treatment schedule and the behavioral parameters evaluated. Methods: We ...
Pharmacology of oral hypoglycemic drugs / Farmakologija oralnih hipoglikemijskih lekova
(Savez farmaceutskih udruženja Srbije, Beograd, 2011)
In patients with diabetes mellitus type 2, non-insulin antihyperglycemic therapy is aimed to control symptoms of hyperglycemia and to limit microvascular complications. It is introduced early after diagnosis of the disease. ...
PsrA Regulator Connects Cell Physiology and Class 1 Integron Integrase Gene Expression Through the Regulation of lexA Gene Expression in Pseudomonas spp.
(Springer, New York, 2019)
Pseudomonas aeruginosa, which is a clinically important representative of Pseudomonas spp., has been recognized as causative agent of severe nosocomial infections worldwide. An increase in antibiotic resistance of P. ...
A stepwise protocol for drug permeation assessment that combines heat-separated porcine ear epidermis and vertical diffusion cells
(Savez hemijskih inženjera, Beograd, 2018)
After decades long absence of an official consensus on the most appropriate evaluation method for in vitro skin performance of topical semisolid drugs, United States Pharmacopoeia (USP 39) finally suggested three types of ...