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Inhaler technique training of community pharmacists and common errors
(European Respiratory Society, 2020)
Introduction: Pharmacists have a significant role in improving patient inhaler technique (HK. Reddel, et al. Eur Respir J 2008;32: 812; Alismail A, et al. Respir Care 2016;61:593). Hence, it is crucial for pharmacists to ...
Discovery of membrane permeability, pharmacokinetics properties and mechanism of action for analogs of ethylenediamine-n,n′-di-2-(3-cyclohexyl)propionic acid and 1,3-propandiamine-n,n′-di-2-(3-cyclohexyl)propionic acid with antiproliferative activity using In Vitro and In Silico Methods
(Springer Verlag, 2020)
In previously in vitro studies on different cell lines and in vivo on melanoma and 4T1 murine breast cancer and metastasis it was shown antiproliferative activity for ester derivatives of (S,S)-ethylenediamine-N,N′-di-2- ...
Application of computational methods for antipsychotic drug design and optimization
(10th International Conference on Biotechnology and Bioengineering (ICBB2020). Dec. 16-18, 2020. Virtual conference, 2020)
Characterization of chitosan/xanthan gum polyelectrolyte complexes as carriers for ibuprofen: influence of drug encapsulation procedure on complex formation
(Macedonian Pharmaceutical AssociationFaculty of Pharmacy, Ss Cyril and Methodius University in Skopje, 2020)
Introduction
Ibuprofen (IBU) is commonly used non-steroidal
anti-inflammatory drug. It is a weak acid (pKa ~4.5)
with low pH dependent aqueous solubility (46
μg/mL at pH 1.5 and ˃300 μg/mL at pH˃7, at 25
°C). The most ...
Characterization of chitosan/xanthan polyelectrolyte complex carriers: influence of drug encapsulation procedure on in vitro release kinetics
(University of Szeged, Institute of Pharmaceutical Technology and Regulatory Affairs, 2020)
Chitosan/xanthan polyelectrolyte complexes (PECs) are considered promising oral drug delivery carriers due to nontoxicity, biodegradability and can be investigated as potential carriers for extended drug release [1,2]. ...
Multitargeting epi-epi drugs for multidrug reistance
(COST Action 17104 (STRATAGEM), 2020)
Epigenetic therapy is now a clinical reality with eight approved drugs that target
DNA methyltransferases, histone deacetylases (HDACs) and lysine
methyltransferases. A further recent development is the concept of ...
Discovery of new 5-HT2A receptor antagonists with a strategy of combining ligand and target-based drug design methodologies
(European Research Network on Signal Transduction (ERNEST) CA18133, 2020)
Reduced cerebellum volume and ataxia-like motoric phenotype in transgenic mouse, carrier of human CYP2C19 gene
(Elsevier, 2020)
Introduction: CYP2C19 transgenic mouse (2C19TG) is generated by the insertion of 12 copies of the human CYP2C19 gene into mouse genome. This animal model is a tool to study the neurodevelopmental role of CYP2C19 in vivo, ...
Estimation of gastrointestinal absorption of a series of dual DNA Gyrase and Topoisomerase IV inhibitors using Pampa technique
(MuTaLig COST ACTION CA15135, 2020)
In this study, estimation of gastrointestinal absorption of thirteen selected dual DNA gyrase and topoisomerase IV
inhibitors was carried out using PAMPA test. Diffusion through artificial membrane, consisting of egg ...
Design of novel thiourea derivatives of naproxen with potential antitumor activity
(COST Action 17104 (STRATAGEM), 2020)
In the search for potent biologically active molecules, thiourea and other structure-related derivatives such as
thiosemicarbazones have attracted great attention. In the past two decades, thiourea derivatives have been ...