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Forced degradation study of torasemide: Characterization of its degradation products
(Taylor & Francis Inc, Philadelphia, 2013)
Torasemide was subjected to forced degradation studies. Stress conditions were varied concerning hydrolysis (acid, base, and neutral), oxidation, photolysis, and thermal degradation in order to identify the potential ...
HPLC evaluation of solvolysis of a novel ester fluocinolone acetonide 21-(2'-phenoxypropionate) in comparison with fluocinonide
(Taylor & Francis Inc, Philadelphia, 2011)
In this study the solvolysis of novel fluocinolone acetonide 21-(2'-phenoxypropionate) in comparison with fluocinonide was analyzed in order to evaluate this process as an in vitro model for prodrug activation. The solvolysis ...
Impurity profiling of mycophenolate mofetil with the assisstance of desirability function in method development
(Taylor & Francis Inc, Philadelphia, 2011)
Multicriteria decision making methodology in combination with experimental design has been applied for optimization of stability-indicating LC/DAD method of Mycophenolate mofetil and its degradation products. Via fractional ...
Analysis of the retention behavior of selected antiarrhythmics by means of thin-layer chromatography
(Taylor & Francis Inc, Philadelphia, 2019)
The retention behavior of ivabradine, its 11 related compounds, diltiazem and verapamil has been examined by thin-layer chromatography using non-polar stationary phase (RP-18) and the following mobile phases: methanol-6.25% ...
Investigation of tropicamide and benzalkonium chloride stability using liquid chromatography
(Taylor & Francis Inc, Philadelphia, 2012)
In this study, a development of stability indicating method (SIM) that could be used to detect a decrease in the amount of tropicamide and benzalkonium chloride due to their degradation is described. In the method development, ...
TLC determination of glimepiride and its main impurities in pharmaceuticals
(Taylor & Francis Inc, Philadelphia, 2013)
A quantitative TLC method was developed for the simultaneous separation and quantification of glimepiride and its main degradation impurities, glimepiride-sulfonamide, and glimepiride-carbamate. Chromatographic analysis ...
TLC determination of tiapride hydrochloride and its impurities in pharmaceuticals
(Taylor & Francis Inc, Philadelphia, 2012)
A simple and sensitive HPTLC method for separation and determination of tiapride hydrochloride and its degradation products has been developed and evaluated. Analysis of tiapride hydrochloride and impurities III, VII, and ...
Estimation of lipophilicity and retention behavior of some alpha adrenergic and imidazoline receptor ligands using rp-tlc
(Taylor & Francis Inc, Philadelphia, 2014)
The chromatographic behavior of 16 alpha adrenergic and imidazoline receptor ligands has been studied by reversed-phase thin-layer chromatography (RP-TLC) on RP-18 and CN stationary phases. Retention constant R-M(0) was ...
Forced degradation studies of simvastatin using microemulsion liquid chromatography
(Taylor & Francis Inc, Philadelphia, 2010)
In this paper, the definition of simvastatin degradation profile by microemulsion liquid chromatography (MELC) is presented. The aim of the study was to investigate simvastatin stability after various stress tests, such ...
Design of Experiments in Optimization and Validation of a Hydrophilic Interaction Liquid Chromatography Method for Determination of Amlodipine Besylate and Bisoprolol Fumarate
(Taylor & Francis Inc, Philadelphia, 2015)
In this paper chemometrically-assisted optimization and validation of hydrophilic interaction liquid chromatographic (HILIC) method for the quantitative analysis of amlodipine besylate (AB) and bisoprolol fumarate (BF) in ...