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Determination of higenamine in dietary supplements by UHPLC/MS/MS method
(Elsevier Science BV, Amsterdam, 2017)
From 1st January 2017 higenamine was added on the WADA (World Anti-doping Agency) Prohibited list under S3 group beta-2 agonists as at all times banned substance for the athletes. The main origine of higenamine (or ...
Hydrophilic interaction liquid chromatography in analysis of granisetron HCl and its related substances. Retention mechanisms and method development
(Elsevier Science BV, Amsterdam, 2016)
In this paper separation of granisetron and its two related substances in HILIC mode is presented. Separation was done on silica column derivatized with sulfoalkylbetaine groups (ZIC-HILIC). Firstly, retention mechanisms ...
Quantitation of pregabalin in dried blood spots and dried plasma spots by validated LC-MS/MS methods
(Elsevier Science BV, Amsterdam, 2015)
In this paper, novel LC-MS/MS methods for the determination of antiepileptic drug pregabalin in dried matrix spots (DMS) are presented. This attractive technique of sample collection in micro amount was utilized in the ...
Chaotropic salts in liquid chromatographic method development for the determination of pramipexole and its impurities following quality-by-design principles
(Elsevier Science BV, Amsterdam, 2015)
The aim of this paper is to present a development of liquid chromatographic method when chaotropic salts are used as mobile phase additives following the QbD principles. The effect of critical process parameters (column ...
Chemometrically assisted development and validation of LC-MS/MS method for the analysis of potential genotoxic impurities in meropenem active pharmaceutical ingredient
(Elsevier Science BV, Amsterdam, 2017)
A sensitive Liquid Chromatography tandem mass spectrometry (LC MS/MS) method was developed and validated for the quantitative analysis of three potential genotoxic impurities (318BP, M9, S5) in meropenem Active Pharmaceutical ...
Quantitation of brinzolamide in dried blood spots by a novel LC-QTOF-MS/MS method
(Elsevier Science BV, Amsterdam, 2016)
In the current study, a rapid and sensitive LC-QTOF-MS/MS method for the determination of brinzolamide in dried blood spots (DBS) was developed and validated. This novel sample collection, storage and transfer technique ...
Quality by Design approach in the development of hydrophilic interaction liquid chromatographic method for the analysis of iohexol and its impurities
(Elsevier Science BV, Amsterdam, 2015)
This study presents the development of hydrophilic interaction liquid chromatographic method for the analysis of iohexol, its endo-isomer and three impurities following Quality by Design (QbD) approach. The main objective ...
Quantitative structure-retention relationship of selected imidazoline derivatives on alpha(1)-acid glycoprotein column
(Elsevier Science BV, Amsterdam, 2016)
The retention behaviour of 22 selected imidazoline drugs and derivatives was investigated on alpha(1)-acid glycoprotein (AGP) column using Sorensen phosphate buffer (pH 7.0) and 2-propanol as organic modifier. Quantitative ...
Quality by Design in the development of hydrophilic interaction liquid chromatography method with gradient elution for the analysis of olanzapine
(Elsevier Science BV, Amsterdam, 2017)
This paper deals with the development of hydrophilic interaction liquid chromatography (HILIC) method with gradient elution, in accordance with Analytical Quality by Design (AQbD) methodology, for the first time. The method ...