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Freeze-dried nanocrystal dispersion of novel deuterated pyrazoloquinolinone ligand (DK-I-56-1): Process parameters and lyoprotectant selection through the stability study
(Elsevier B.V., 2023)
Recently, nanocrystal dispersions have been considered as a promising formulation strategy to improve the bioavailability of the deuterated pyrazoloquinolinone ligand DK-I-56-1 (7‑methoxy-2-(4‑methoxy-d3-phenyl)-2,5-dihy ...
Subacute Exposure to Low Pb Doses Promotes Oxidative Stress in the Kidneys and Copper Disturbances in the Liver of Male Rats
(MDPI, 2023)
Recent data indicate that lead (Pb) can induce adverse effects even at low exposure levels. Moreover, the corresponding mechanisms of low Pb toxicity have not been well identified. In the liver and the kidneys, Pb was found ...
Carcinogenic and human health risk assessment of children’s and adults’ exposure to toxic metal(oid)s from air PM10 in critical sites of the Republic of Serbia
(Springer Nature, 2023)
With global urbanization and industrialization, air pollution has become an inevitable problem. Among air pollutants, toxic metals bound to particulate matter (PM) have a high hazardous potential, contributing to the ...
Biopolymers in Mucoadhesive Eye Drops for Treatment of Dry Eye and Allergic Conditions: Application and Perspectives
(MDPI, 2023)
Dry eye syndrome and allergic conjunctivitis are the most common inflammatory disorders of the eye surface. Although eye drops are the most usual prescribed dosage form, they are characterized by low ocular availability ...
Recovering the Soybean Hulls after Peroxidase Extraction and Their Application as Adsorbent for Metal Ions and Dyes
(Hindawi, 2023)
This study is aimed at extending the soybean hulls' lifetime by their utilization as an adsorbent for metal ions (Cd2+ and Cu2+) and dyes (Reactive Yellow 39 (RY 39) and Acid Blue 225 (AB 225)). ATR-FTIR spectroscopy, ...
Derivation of benchmark doses for male reproductive toxicity in a subacute low-level Pb exposure model in rats
(Elsevier Ireland Ltd, 2023)
The objectives of the study were to simulate low-level Pb exposure scenario in an animal model and to examine reproductive adverse effects. Based on obtained data, we have performed Benchmark dose (BMD)-response modelling. ...
Predictors of Inadequate Health Literacy among Patients with Type 2 Diabetes Mellitus: Assessment with Different Self-Reported Instruments
(MDPI, 2023)
INTRODUCTION: Obtaining, understanding, interpreting, and acting on health information enables people with diabetes to engage and make health decisions in various contexts. Hence, inadequate health literacy (HL) could pose ...
A novel positive modulator of alpha 4-GABAA receptors, XHe-III-74, reduces ethanol intake in mouse "drinking in the dark" model
(Elsevier Science BV, Amsterdam, 2019)
Application of Machine-Learning Algorithms for Better Understanding the Properties of Liquisolid Systems Prepared with Three Mesoporous Silica Based Carriers
(MDPI, 2023)
The processing of liquisolid systems (LSS), which are considered a promising approach
to improving the oral bioavailability of poorly soluble drugs, has proven challenging due to the
relatively high amount of liquid phase ...
Square wave voltammetric study of interaction between 9-acridinyl amino acid derivatives and DNA
(Elsevier B.V., 2023)
Electrochemical oxidation of newly synthesized acridine derivatives (ADs): PG, PA, EG and EA was studied using square wave voltammetry at a glassy carbon electrode. Oxidation occurs as an irreversible process for all ADs. ...