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Electrochemical and theoretical study on interaction between erlotinib and DNA
(Elsevier B.V., 2023)
A comprehensive investigation of tyrosine kinase inhibitor erlotinib (ERL) electrochemical behavior and interaction with DNA was performed with the aim to clarify its redox mechanism and to determine the mode of binding. ...
Bioequivalence of Different Formulations of Zonisamide Oral Suspensions: A Short Review
(Dove Medical Press Ltd, 2023)
To satisfy the needs of pediatric and other patients with focal onset seizures who cannot swallow solid dosage forms of zonisamide, an oral liquid form of this drug is necessary in clinical practice. Although there are two ...
Structure-Based Design of Selective Histone Deacetylase 6 Zinc Binding Groups
(Taylor & Francis, 2019)
The binding site of the second catalytic domain of human histone deacetylase 6 (HDAC6 CDII) has structural features that differ from the other human orthologues, being also mainly responsible for the overall enzymatic ...
Tailoring the electrochemical charge storage properties of carbonaceous support by redox properties of heteropoly acids: where does the synergy come from?
(Springer, 2019)
The synergistic effects between two Keggin-type heteropoly acids (HPAs) and carbon surface were examined and elucidated. An improved high rate capability (and potential high capacitor electrode for supercapacitors) of the ...
COVID-19 signalome: Potential therapeutic interventions
(Elsevier Inc., 2023)
The COVID-19 pandemic has triggered intensive research and development of drugs and vaccines against SARS-CoV-2 during the last two years. The major success was especially observed with development of vaccines based on ...
A Comparative Study of Chamomile Essential Oils and Lipophilic Extracts Obtained by Conventional and Greener Extraction Techniques: Chemometric Approach to Chemical Composition and Biological Activity
(MDPI, 2023)
Bearing in mind the centuries-old traditional use of chamomile, but also the increasing demand for its products in modern industry, oriented toward sustainable development, there are increasing efforts for the efficient ...
ORR Catalysts Derived from Biopolymers
(MDPI, 2023)
Due to the limited reaction rate of the oxygen reduction reaction (ORR), it is considered as a limiting factor in the performance of fuel cells and metal-air batteries. Platinum is considered the benchmark catalyst for ...
The Role of Advanced Glycation End Products on Dyslipidemia
(MDPI, 2023)
Disorders of lipoprotein metabolism and glucose homeostasis are common consequences of insulin resistance and usually co-segregate in patients with metabolic syndrome and type 2 diabetes mellitus (DM). Insulin-resistant ...
Analytical method development supported by DoE-DS approach for enantioseparation of (S,S)- and (R,R)-moxifloxacin
(Elsevier B.V., 2023)
In this paper, method for enantiomeric purity testing of fourth-generation fluoroquinolone, moxifloxacin hydrochloride, was developed and validated. Exceptional enantioselectivity for this assay was achieved using cyclodextrin ...
Instability Induced by Random Background Noise in a Delay Model of Landslide Dynamics
(MDPI, 2023)
In the present paper, we propose a new model for landslide dynamics, in the form of the spring-block mechanical model, with included delayed interaction and the effect of the background seismic noise. The introduction of ...