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Optimization of technological procedure for amygdalin isolation from plum seeds (Pruni domesticae semen)
(Frontiers Media Sa, Lausanne, 2015)
The process of amygdalin extraction from plum seeds was optimized using central composite design (CCD) and multilayer perceptron (MLP). The effect of time, ethanol concentration, solid-to-liquid ratio, and temperature on ...
Are GABA(A) receptors containing alpha 5 Subunits contributing to the sedative properties of benzodiazepine site agonists?
(Nature Publishing Group, London, 2008)
Classical benzodiazepines (BZs) exert anxiolytic, sedative, hypnotic, muscle relaxant, anticonvulsive, and amnesic effects through potentiation of neurotransmission at GABA(A) receptors containing alpha(1), alpha(2), ...
Environmental cadmium exposure and pancreatic cancer: Evidence from case control, animal and in vitro studies
(Pergamon-Elsevier Science Ltd, Oxford, 2019)
Although profoundly studied, etiology of pancreatic cancer (PC) is still rather scarce. Some of established risk factors of PC are connected to an increased cadmium (Cd) body burden. Hence, the aim of this study was to ...
Triggered dynamics in a model of different fault creep regimes
(Nature Publishing Group, London, 2014)
The study is focused on the effect of transient external force induced by a passing seismic wave on fault motion in different creep regimes. Displacement along the fault is represented by the movement of a spring-block ...
In vitro - in vivo - in silico approach in the development of inhaled drug products: Nanocrystal-based formulations with budesonide as a model drug
(Elsevier B.V., 2021)
This study aims to understand the absorption patterns of three different kinds of inhaled formulations via in silico modeling using budesonide (BUD) as a model drug. The formulations investigated in this study are: (i) ...
International Union of Basic and Clinical Pharmacology. CVI: GABAA Receptor Subtype- and Function-selective Ligands: Key Issues in Translation to Humans
(Amer Soc Pharmacology Experimental Therapeutics, Bethesda, 2018)
GABAA receptors are themajor inhibitory transmitter receptors in the brain. They are ligand-gated chloride channels and the site of action of benzodiazepines, barbiturates, neuroactive steroids, anesthetics, and convulsants. ...
The Polymorphic Nuclear Factor NFIB Regulates Hepatic CYP2D6 Expression and Influences Risperidone Metabolism in Psychiatric Patients
(John Wiley and Sons Inc, 2022)
The genetic background for interindividual variability of the polymorphic CYP2D6 enzyme activity remains incompletely understood and the role of NFIB genetic polymorphism for this variability was evaluated in this translational ...
Charged aerosol detector response modeling for fatty acids based on experimental settings and molecular features: a machine learning approach
(BioMed Central Ltd, 2021)
The charged aerosol detector (CAD) is the latest representative of aerosol-based detectors that generate a response independent of the analytes’ chemical structure. This study was aimed at accurately predicting the CAD ...
Association of acute Babesia canis infection and serum lipid, lipoprotein, and apoprotein concentrations in dogs
(Blackwell Publishing Inc., 2019)
Background: Babesia canis infection induces a marked acute phase response (APR) that might be associated with alteration in lipid and lipoprotein metabolism and disease prognosis. Hypothesis: Dogs with B. canis-induced APR ...
Drug use before and during pregnancy in republic of Serbia
(Elsevier, 2009)
OBJECTIVES: To investigate drug use six months before (SMBP) and during preg-
nancy (DP) among Serbian pregnant women (SPW). METHODS: Pharmacy based
cross-sectional survey was conducted among SPW between March through ...