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Combined Application of Experimental Design and Artificial Neural Networks in Modeling and Characterization of Spray Drying Drug: Cyclodextrin Complexes
(Taylor & Francis Inc, Philadelphia, 2014)
The aim of this study was to investigate the usefulness of combined application of quality by design tools such as central composite design (CCD), response surface methodology (RSM), and artificial neural networks (ANN) ...
The impact of storage on the primary and secondary metabolites, antioxidant activity and digestibility of oat grains (Avena sativa)
(Elsevier Science BV, Amsterdam, 2014)
The effect of storage was studied on grain metabolites, functional properties and digestibility of three oat cultivars selected in Serbia - Dunav, Vrbas and NS Tara. During the 12 and 24 months of storage, there was a ...
Solid lipid nanoparticles (SLN) stabilized with polyhydroxy surfactants: Preparation, characterization and physical stability investigation
(Elsevier Science BV, Amsterdam, 2014)
Polyhydroxy surfactants are nonionic ethylene oxide free stabilizers known for their complimentary dermatological properties and favorable environmental profile. The aim of this study was to develop solid lipid nanoparticles ...
Polymorphisms of Beta2-Adrenergic Receptor Gene in Serbian Asthmatic Adults: Effects on Response to Beta-Agonists
(Adis Int Ltd, Northcote, 2014)
Background and Objectives Polymorphisms of beta2-adrenergic receptor gene (ADRB2) are clinically relevant for several reasons, including as a risk factor for asthma development/severity and predicting the effectiveness of ...
Viscosity-mediated negative food effect on oral absorption of poorly-permeable drugs with an absorption window in the proximal intestine: In vitro experimental simulation and computational verification
(Elsevier Science BV, Amsterdam, 2014)
Concomitant food intake can diminish oral absorption of drugs with limited permeability and an absorption window in the proximal intestine, due to viscosity-mediated decrease in dosage form disintegration time and drug ...
Linking industry and academia in teaching pharmaceutical development and manufacture (LIAT-Ph)
(Euromed Communications, 2014)
The pharmaceutical industry continues to develop to respond to challenges of an ageing population and more complex medicinal products. Advances in pharmaceutical development include a shift towards quality-by-design, the ...
Long-chain n-3 polyunsaturated fatty acid dietary recommendations are moderately efficient in optimizing their status in healthy middle-aged subjects with low fish consumption: a cross-over study
(Pergamon-Elsevier Science Ltd, Oxford, 2014)
Several dietary recommendations have been made for marine n-3 polyunsaturated fatty acid (PUPA) intake; however, the effectiveness of these fatty acids has not been thoroughly examined. The aim of this study was to investigate ...
Solid self-emulsifying phospholipid suspension (SSEPS) with diatom as a drug carrier
(Elsevier Science BV, Amsterdam, 2014)
We report the application of diatom as a solid carrier for water insoluble drugs applied in oral drug delivery system based on the self-emulsifying drug delivery system (SEDDS) caprylocaproyl macrogol-8 glycerides/lecith ...
Application of D-optimal experimental design method to optimize the formulation of O/W cosmetic emulsions
(Wiley, Hoboken, 2014)
ObjectiveThis study investigates the application of D-optimal mixture experimental design in optimization of O/W cosmetic emulsions. Cetearyl glucoside was used as a natural, biodegradable non-ionic emulsifier in the ...
Retention mechanism assessment and method development for the analysis of iohexol and its related compounds in hydrophilic interaction liquid chromatography
(Springer Heidelberg, Heidelberg, 2014)
Hydrophilic interaction liquid chromatography (HILIC) has emerged in recent years as a valuable alternative to reversed-phase liquid chromatography in the analysis of polar compounds. Research in HILIC is divided into two ...