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Biopharmaceutical characterization of carbamazepine immediate release tablets - In vitro-in vivo comparison
(ECV-Editio Cantor Verlag Medizin Naturwissenschaften, Aulendorf, 2007)
A growing concern for the biopharmaceutical characterization of pharmaceutical products increased the interest in the evaluation and identification of physicochemical properties of drugs and dosage forms that govern its ...
Justification of Biowaiver for Carbamazepine, a Low Soluble High Permeable Compound, in Solid Dosage Forms Based on IVIVC and Gastrointestinal Simulation
(Amer Chemical Soc, Washington, 2009)
The aim of the present study was to use gastrointestinal simulation technology and in vitro-in vivo correlation (IVIVC) as tools to investigate a possible extension of biowaiver criteria to BCS class II drugs using ...
Population pharmacokinetic model of carbamazepine derived from routine therapeutic drug monitoring data
(Lippincott Williams & Wilkins, Philadelphia, 2007)
The aim of the present study was to develop a population pharmacokinetic model of carbamazepine from routine therapeutic drug monitoring data. Steady-state carbamazepine plasma concentrations determined by homogenous enzyme ...
The examination of antinociceptive and toxic effects of oxcarbazepine and carbamazepine in mice
(Blackwell Publishing, Oxford, 2006)
Moclobemide monotherapy vs. combined therapy with valproic acid or carbamazepine in depressive patients: a pharmacokinetic interaction study
(Wiley, Hoboken, 2009)
WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT center dot Moclobemide (MCB) undergoes extensive both presystemic and systemic metabolism that can be affected by concomitant drugs. center dot Valproic acid (VPA) and carbamazepine ...
The effects of alpha(2)-adrenoceptor agents on anti-hyperalgesic effects of carbamazepine and oxcarbazepine in a rat model of inflammatory pain
(Elsevier Science BV, Amsterdam, 2006)
In this study, the effects of yohimbine (alpha(2)-adrenoceptor antagonist) and clonidine (alpha(2)-adrenoceptor agonist) on anti-hyperalgesia induced by carbamazepine and oxcarbazepine in a rat model of inflammatory pain ...
Role of alpha 2-adrenoceptors in the local peripheral antinociception by carbamazepine in a rat model of inflammatory mechanical hyperalgesia
(Prous Science, Sa, Barcelona, 2007)
The anticonvulsant carbamazepine was recently shown to possess local peripheral antinociceptive properties. In this study, we investigated whether alpha 2-adrenergic receptors are involved in the local peripheral ...
Opioidergic mechanisms are not involved in the antihyperalgesic effects of carbamazepine and oxcarbazepine
(Prous Science, Sau-Thomson Reuters, Barcelona, 2007)
The mechanisms of the analgesic action of carbamazepine and oxcarbazepine, in particular the role of opioid receptors, have not been established precisely. The systemic effects of naloxone, an opioid receptor antagonist, ...
Development of a drug release methodology for carbamazepine CR tablets based on bioequivalence evaluation
(Editions Sante, Paris, 2008)
The aim of this study was to investigate the influence of experimental conditions on carbamazepine (CBZ) release from the two controlled-release (CR) tablet formulations with proven bioequivalence and to propose the universal ...