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Mechanistic simulation of carbamazepine absorption after oral administration of immediate release tablets / In silico predviđanje apsorpcije karbamazepina nakon oralne primene tableta sa trenutnim oslobađanjem
(Savez farmaceutskih udruženja Srbije, Beograd, 2012)
The main prerequisite to establish quantitative in vitro-in vivo correlation (IVIVC) and define biorelevant in vitro methodology is to identify drug dissolution profile in vivo. When intravenous data are not available due ...
Improvement of Aripiprazole Solubility by Complexation with (2-Hydroxy)propyl-beta-cyclodextrin Using Spray Drying Technique
(Springer, New York, 2012)
Due to the fact that the number of new poorly soluble active pharmaceutical ingredients is increasing, it is important to investigate the possibilities of improvement of their solubility in order to obtain a final ...
A case study on the in silico absorption simulations of levothyroxine sodium immediate-release tablets
(Wiley-Blackwell, Malden, 2012)
The aim of this case study was to develop a drug-specific absorption model for levothyroxine (LT4) using mechanistic gastrointestinal simulation technology (GIST) implemented in the GastroPlus (TM) software package. The ...
Development and optimization of formulation for treatment of copper deficiency in human organism
(Polskie Towarzystwo Farmaceutyczne, Warsaw, 2012)
The aim of this study was to design and optimize a new tablet formulation for treatment of copper deficiency in human organism by using an experimental design. The new no-veneered tablets, prepared by a wet granulation ...