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Pyrrolidine derived thioureas as organocatalysts in the Michael reaction of vinyl sulfone. Structure-stereoselectivity study
(Pergamon-Elsevier Science Ltd, Oxford, 2016)
Structural variations of the heterocyclic ring of the recently introduced pyrrolidine derived thiourea organocatalysts have been studied. The results showed that the stereoselectivity is highly dependent on the substitution ...
Quantitative structure-retention relationship of selected imidazoline derivatives on alpha(1)-acid glycoprotein column
(Elsevier Science BV, Amsterdam, 2016)
The retention behaviour of 22 selected imidazoline drugs and derivatives was investigated on alpha(1)-acid glycoprotein (AGP) column using Sorensen phosphate buffer (pH 7.0) and 2-propanol as organic modifier. Quantitative ...
Cordyceps sinensis: Genotoxic Potential in Human Peripheral Blood Cells and Antigenotoxic Properties Against Hydrogen Peroxide by Comet Assay
(Innovision Communications, Aliso Viejo, 2016)
Context Cordyceps sinensis (C sinensis) is a well-known, traditional, Chinese medicinal mushroom, valued for its beneficial properties for human health. C sinensis has been reported to have immunomodulatory, anticancer, ...
Antibacterial and cytotoxic activities of wild mushroom Fomes fomentarius (L.) Fr., Polyporaceae
(Elsevier Science BV, Amsterdam, 2016)
The antibacterial activity of cyclohexane, dichlormethane, methanol and aqueous extracts of tinder fungus Fomes fomentarius (L) Fr (Polyporaceae) was tested against 9 bacterial strains (Staphylococcus aureus, Staphylococcus ...
Synthesis of the vitamin E amino acid esters with an enhanced anticancer activity and in silico screening for new antineoplastic drugs
(Elsevier Science BV, Amsterdam, 2016)
Tocopherols and tocotrienols belong to the family of vitamin E (VE) with the well-known antioxidant properties. For certain alpha-tocopherol and gamma-tocotrienol derivatives used as the lead compounds in this study, ...
Performance and Efficiency of Anionic Dishwashing Liquids with Amphoteric and Nonionic Surfactants
(Wiley, Hoboken, 2016)
Performance and efficiency of anionic [sodium lauryl ether sulfate (SLES) and sodium alpha-olefin sulfonate (AOS)] and amphoteric [cocamidopropyl betaine (CAB)] as well as nonionic [cocodiethanol amide (DEA), various ...
Quantitative structure-retention relationships applied to development of liquid chromatography gradient-elution method for the separation of sartans
(Elsevier Science BV, Amsterdam, 2016)
QSRR are mathematically derived relationships between the chromatographic parameters determined for a representative series of analytes in given separation systems and the molecular descriptors accounting for the structural ...
Formulation of hydrogel-thickened nonionic microemulsions with enhanced percutaneous delivery of ibuprofen assessed in vivo in rats
(Elsevier Science BV, Amsterdam, 2016)
The study investigated usage of hydrogel of an anionic polymer xanthan gum for design of ibuprofen-loaded hydrogel-thickened microemulsions (HTMs) from the nonionic oil-in-water microemulsion (M). Xanthan gum demonstrated ...
Application of the design of experiments in optimization of drug layering of pellets with an insight into drug polymer interactions
(Elsevier Science BV, Amsterdam, 2016)
This study consists of two experimental designs. Within the first one, suitable technique for application of model drug onto inactive pellets was evaluated and formulation and process parameters with greatest impact to ...
Biomarkers for Major Depressive Disorder: Economic Considerations
(Wiley, Hoboken, 2016)
Major depressive disorder (MDD) is a major psychiatric illness and it is predicted to be the second leading cause of disability by 2020 with a lifetime prevalence of about 13%. Selective serotonin reuptake inhibitors (SSRIs) ...