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Moclobemide monotherapy vs. combined therapy with valproic acid or carbamazepine in depressive patients: a pharmacokinetic interaction study
(Wiley, Hoboken, 2009)
WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT center dot Moclobemide (MCB) undergoes extensive both presystemic and systemic metabolism that can be affected by concomitant drugs. center dot Valproic acid (VPA) and carbamazepine ...
Premature centromere division of the X chromosome in neurons in Alzheimer's disease
(Wiley-Blackwell, Malden, 2008)
Premature centromere division (PCD) represents a loss of control over the sequential separation and segregation of chromosome centromeres. Although first described in aging women, PCD on the X chromosome (PCD,X) is markedly ...
Cost of outpatient hypertension pharmacotherapy-comparative study between Bulgaria and Serbia
(Elsevier Science Inc, 2008)
OBJECTIVES: Pharmacotherapy costs represents huge burden
for health institutions. The aim of the study is to compare pre-
scribing practice and cost of outpatient hypertension pharmaco-
therapy between Bulgaria and ...
Comparative analysis of the access to pharmaceuticals in selected east European countries
(Elsevier Science Inc, 2008)
OBJECTIVE: The purpose of this work is to evaluate the access
to pharmaceuticals and system in three European neighboring countries (Slovenia, Bulgaria and Serbia) by the selected indica-
tors. METHODS: Retrospective ...
An Investigation into the Importance of "Very Rapid Dissolution" Criteria for Drug Bioequivalence Demonstration using Gastrointestinal Simulation Technology
(Springer, New York, 2009)
The Biopharmaceutics Classification System (BCS) is based on the mechanistic assumptions that the rate and extent of oral drug absorption are governed by drug solubility, intestinal permeability, and dissolution rate from ...
Reactive organoallyl species generated from aryl halides and allene: allylation of alpha,beta-unsaturated aldehydes and cyclic ketones employing Pd/In transmetallation processes
(Pergamon-Elsevier Science Ltd, Oxford, 2008)
Allylation of alpha,beta-unsaturated aldehydes and cyclic ketones promoted by Pd/In transmetallation processes has been Studied. The unsaturated aldehydes underwent regioselective 1,2-addition to afford secondary homoally ...