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Rilmenidine binds to and inhibits the activity of MDR pumps in pancreatic ductal adenocarcinoma
(COST Action 17104 (STRATAGEM), 2022)
Pancreatic ductal adenocarcinoma (PDAC) is the sixth leading cause of death worldwide and the fourth
in Europe with a 5-year survival rate. The common cause of treatment failure in PDAC patients is
multidrug resistance ...
Application of computational methods for antipsychotic drug design and optimization
(10th International Conference on Biotechnology and Bioengineering (ICBB2020). Dec. 16-18, 2020. Virtual conference, 2020)
Molecular modeling of 5 [(amidobenzyl)oxy] nicotinamides as sirtuin 2 inhibitors using alignment - (in)dependent 3D-QSAR analysis and molecular docking
(Institute for Information Technologies, University of Kragujevac, Serbia, 2021)
The group of 5 [(amidobenzyl)oxy] nicotinamides
(SIRT2) inhibitors. Despite structural similarity, representatives of this group of inhibitors
displayed versatile mechanisms of inhibition which hamper rational drug design. ...
Virtual Docking, design and in silico ADMET profiling of novel Rho- associated protein kinases-1 (ROCK1) inhibitors
(Institute for Information Technologies, University of Kragujevac, Serbia, 2023)
Overexpression of Rho-associated protein kinases has been associated with various
diseases, including tumors. None of the approved ROCK inhibitors are used for cancer treatment.
However, some of them have been shown to ...
In vitro and in silico investingation of antimicrobial activity of essential oils from two Pastinaca sativa subspecies
(University Prince of Songkla, ThailandUniversity of Novi Sad, Faculty of Sciences, Serbia, Novi Sad, 2021)
INTRODUCTION:
Cultivated parsnip (Pastinaca sativa subsp. sativa L., Apiaceae) root is a well-known vegetable, common ingredient of soups, stews, salads, casseroles etc. Besides, its leaves and young shoots can be added ...
Molecular Docking Analysis of Novel Thiourea Derivatives of Naproxen with Potential Anti-Inflammatory Activity
(MDPI, 2022)
Administration of current non-steroidal anti-inflammatory drugs is often associated with
serious adverse effects. Therefore, there is a constant need to develop new molecules with anti-
inflammatory activity. On the other ...