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α6-Containing GABAA Receptors: Functional Roles and Therapeutic Potentials
(American Society for Pharmacology and Experimental Therapy, 2022)
GABAA receptors containing the α6 subunit are highly expressed in cerebellar granule cells and less abundantly in many other neuronal and peripheral tissues. Here, we for the first time summarize their importance for the ...
Study of chitosan/xanthan gum polyelectrolyte complexes formation, solid state and influence on ibuprofen release kinetics
(Elsevier B.V., 2020)
This study investigated the combined influence of pH adjusting agent type (hydrochloric, acetic or lactic acid) and initial pH value (3.6, 4.6, and 5.6) on formation of biocompatible chitosan/xanthan polyelectrolyte complexes ...
EFFECT of colored noise on the generation of seismic fault MOVEMENT: Analogy with spring-block model DYNAMICS
(Elsevier, 2020)
In present paper authors examined the effect of colored noise on the onset of seismic fault motion. For this purpose, they analyze the dynamics of spring-block model, with 10 all-to all coupled blocks. This spring-block ...
Defining the importance of stress reduction in managing cardiovascular disease - the role of exercise
(W.B. Saunders, 2022)
Traditional risk factors for cardiovascular disease (CVD) have long been the focus of preventive strategies. The impact of family stress, depression, anxiety, hostility, pessimism, job strain, social isolation, lack of ...
Health Benefits and Applications of Goji Berries in Functional Food Products Development: A Review
(MDPI, 2022)
Goji berries have long been used for their nutritional value and medicinal purposes in Asian countries. In the last two decades, goji berries have become popular around the world and are consumed as a functional food due ...
Quality benchmarking of smartphone laboratory medicine applications: Comparison of laboratory medicine specialists' and non-laboratory medicine professionals' evaluation
(De Gruyter Open Ltd, 2021)
There are many mobile health applications (apps) now available and some that use in some way laboratory medicine data. Among them, patient-oriented are of the lowest content quality. The aim of this study was to compare ...
Gradient Boosted Tree model: A fast track tool for predicting the Atmospheric Pressure Chemical Ionization-Mass Spectrometry signal of antipsychotics based on molecular features and experimental settings
(Elsevier B.V., 2022)
Predicting the response signal in Atmospheric Pressure Chemical Ionization - Mass Spectrometry (APCI-MS) systems appears to be considerably challenging due to a gap in knowledge of governing factors and nature of their ...
In vitro - in vivo - in silico approach in the development of inhaled drug products: Nanocrystal-based formulations with budesonide as a model drug
(Elsevier B.V., 2021)
This study aims to understand the absorption patterns of three different kinds of inhaled formulations via in silico modeling using budesonide (BUD) as a model drug. The formulations investigated in this study are: (i) ...
Charged aerosol detector response modeling for fatty acids based on experimental settings and molecular features: a machine learning approach
(BioMed Central Ltd, 2021)
The charged aerosol detector (CAD) is the latest representative of aerosol-based detectors that generate a response independent of the analytes’ chemical structure. This study was aimed at accurately predicting the CAD ...
Synergism between metformin and analgesics/vitamin B12 in a model of painful diabetic neuropathy
(Elsevier Masson s.r.l., 2022)
Metformin (a widely used antidiabetic drug) has demonstrated efficacy in models of painful diabetic neuropathy
(PDN), as well as certain clinical efficacy in relieving/preventing PDN. This study aimed to determine the ...