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pH-sensitive microparticles for oral drug delivery based on alginate/oligochitosan/Eudragit (R) L100-55 "sandwich" polyelectrolyte complex
(Elsevier Science BV, Amsterdam, 2013)
The primary objective of this study was to investigate the influence of the oligochitosan-Eudragit (R) L100-55 polyelectrolyte complex (OCH-EL PEC) on the pH-sensitivity of Eudragit (R) L100-55-treated alginate-oligochitosan ...
Potential Influence of Tubular Dysfunction on the Difference Between Estimated and Measured Glomerular Filtration Rate After Kidney Transplantation
(Elsevier Science Inc, New York, 2013)
Purpose. Because no consensus exists regarding the most accurate calculation to estimate glomerular filtration rate (GFR) based on serum creatinine concentrations (sCr) after kidney transplantation, this study sought to ...
Relationship between bone resorption, oxidative stress and inflammation in severe COPD exacerbation
(Pergamon-Elsevier Science Ltd, Oxford, 2013)
Background: The natural course of chronic obstructive pulmonary disease (COPD) is complicated by the development of systemic consequences and co-morbidities. Increasing evidence indicates that COPD and osteoporosis are ...
The interface of hypothalamic-pituitary-adrenocortical axis and circulating brain natriuretic peptide in prediction of cardiopulmonary performance during physical stress
(Elsevier Science Inc, New York, 2013)
Brain natriuretic peptide (NT-pro-BNP) was implicated in the regulation of hypothalamic-pituitary-adrenocortical (HPA) responses to psychological stressors. However, HPA axis activation in different physical stress models ...
Imidazoline-1 Receptor Ligands as Apoptotic Agents: Pharmacophore Modeling and Virtual Docking Study
(Bentham Science Publ Ltd, Sharjah, 2013)
The group of imidazoline-1 receptors (I-1-IR) agonists encompasses drugs are currently used in treatment of high blood pressure and hyperglycemia. The I-1-IR protein structures have not been determined yet, but Nischarin ...
Hyperlipidemia, oxidative stress, and intima media thickness in children with chronic kidney disease
(Springer, New York, 2013)
The roles of dyslipidemia and oxidative stress in the early phases of atherosclerosis were tested in children with chronic kidney disease (CKD). Intima media thickness of common carotid arteries (cIMT) is used as a measure ...
Spray-dried voriconazole-cyclodextrin complexes: Solubility, dissolution rate and chemical stability
(Elsevier Sci Ltd, Oxford, 2013)
The present work investigates the effect of complexation with hydroxypropyl-beta-cyclodextrin (HPBCD) and 2-O-methyl-beta-cyclodextrin (2-O-MBCD), on voriconazole solubility, dissolution rate and chemical stability. ...
Gonadal hormone dependent developmental plasticity of catecholamine:beta 2-adrenoceptor signaling complex in male rat thymus: Putative implications for thymopoiesis
(Elsevier Science BV, Amsterdam, 2013)
The study was undertaken considering that: i) androgens affect beta(2)-adrenoceptor (AR)-mediated catecholamine (CA) action in many tissues; and ii) peripubertal changes in both circulating androgen and thymic CA levels ...
Adrenal hormone deprivation affects macrophage catecholamine metabolism and 2-adrenoceptor density, but not propranolol stimulation of tumour necrosis factor- production
(Wiley-Blackwell, Hoboken, 2013)
New Findings center dot What is the central question of this study? Glucocorticoids modulate extraglandular catecholamine metabolism and adrenoceptor expression in many cell types. Catecholamines modulate the production ...