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Probiotic reduced the impact of phthalates and bisphenol A mixture on type 2 diabetes mellitus development: Merging bioinformatics with in vivo analysis
(Elsevier, 2021)
Linkage between bis(2-ethylhexyl) phthalate (DEHP), dibutyl phthalate (DBP), and bisphenol A (BPA) coexposure and type 2 diabetes mellitus (T2DM), as well as ability of multi-strained probiotic to reduce DEHP, DBP and BPA ...
Oxidative stress in the rats brain capillaries in sepsis - The influence of 7-nitroindazole
(Acta Physiologica Hungarica, 2006)
As a part of blood-brain barrier, brain capillaries participate in pathophysiological events during systemic inflammation. We investigated the effects of 7-nitroindazole (7-NI), selective neuronal nitric oxide synthase ...
Oxidative stress status assessment of rats' brains injury following subacute exposure to K-oximes
(Elsevier B.V., 2023)
Oxidative stress status and morphological injuries in the brain of Wistar rats induced by repeated application of selected acetylcholinesterase reactivators - asoxime, obidoxime, K027, K048, K074, and K075 were evaluated. ...
Possible role of lead in breast cancer — a case-control study
(Springer Nature, 2022)
Numerous risk factors have been associated with breast cancer (BC), exposure to metalloestrogen, like lead, being such. Since lead involvement in BC is still equivocal, we focused on lead levels in three compartments of ...
DNA, protein and lipid oxidative damage in tissues of spontaneously hypertensive versus normotensive rats
(Elsevier Ltd, 2021)
Oxidative damage to protein and lipid macromolecules in target organs in hypertension has been recognized as a major factor contributing to cardiovascular, cerebrovascular, and renal diseases. Data on protein and lipid ...
New insight into the perplexing toxic features of PCBs: A study of nephrotoxicity in an animal model
(Elsevier Inc, 2023)
The present study investigated the effects of PCBs on the rat kidneys with attention given to the determination critical effect dose (CED) using the Benchmark dose (BMD) approach. Male albino Wistar rats (7 animals per ...
An overview of molecular mechanisms in cadmium toxicity
(Current Opinion in Toxicology, 2020)
Cadmium (Cd), one of the most important environmental pollutants, can cause a number of toxic effects. These effects are the result of more than one mechanisms of toxicity, all interrelated in their complexity. Thus, it ...
Low-lead doses induce oxidative damage in cardiac tissue: Subacute toxicity study in Wistar rats and Benchmark dose modelling
(Elsevier Ltd, 2022)
Exposure to toxic metals, including lead (Pb), were found as important risk factor for cardiovascular diseases. The aim of the study was to simulate low-level subacute Pb exposure scenario and to determine redox status, ...
Fluoride subacute testicular toxicity in Wistar rats: Benchmark dose analysis for the redox parameters, essential elements and DNA damage
(Elsevier Ltd, 2022)
Excessive fluoride (F−) levels in the environment could induce different pathological changes, including comorbidities in reproductive functions. Hence, the aim of the present in vivo study was to explore F− subacute ...
Neurotoxic effects of low dose ranges of environmental metal mixture in a rat model: The benchmark approach
(Elsevier Inc., 2024)
Metals exert detrimental effects on various systems within the body, including the nervous system. Nevertheless, the dose-response relationship concerning the administration of low doses of metal mixtures remains inadequately ...