The Influence of Maternal Smoking Habits Before Pregnancy and Antioxidative Supplementation During Pregnancy on Oxidative Stress Status in a Non-Complicated Pregnancy
2014
Аутори
Ardalić, DanielaStefanović, Aleksandra
Kotur-Stevuljević, Jelena
Vujović, Ana
Spasić, Slavica
Spasojević-Kalimanovska, Vesna
Jelić-Ivanović, Zorana
Mandić-Marković, Vesna
Miković, Željko
Cerović, Nikola
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Background. As a physiological condition closely linked with increased susceptibility to oxidative stress, pregnancy can be further compromised by cigarette smoking. Inadequate nutrition and reduced intake of antioxidants can also disrupt the prooxidant/antioxidant relationship and contribute to oxidative stress. Increased oxidative stress during pregnancy may be involved in several complications of pregnancy, such as preterm labor, fetal growth restriction, preeclampsia and Miscarriage. Objectives. The aim of this study was to investigate the influence of maternal smoking habits before pregnancy on the parameters of oxidative stress and the antioxidative defense system, lipid profile parameters and paraoxonase-1 (PON1) activity during the third trimester of uncomplicated pregnancies. Material and Methods. Healthy pregnant women (n = 86) were divided into non-smoking and smoking groups, and into groups taking vitamin supplements and not taking them. Oxidative damage was measured throug...h the levels of thiobarbituric acid-reacting substances (TBARS) and plasma antioxidant status was evaluated by measuring total antioxidant capacity (TAC). Results. TBARS concetration was significantly higher (p lt 0.05) and PON1 activity was significantly lower (p lt 0.05) in the smokers' group. No significant differences were found in the investigated parameters in relation to vitamin supplement intake. Conclusions. Habitual smoking before pregnancy is associated with increased oxidative stress. Vitamin supplementation has no effect on the oxidative stress status of healthy pregnant women.
Кључне речи:
pregnancy / oxidative stress / habitual maternal smoking / antioxidative supplementationИзвор:
Advances in Clinical and Experimental Medicine, 2014, 23, 4, 575-583Издавач:
- Wroclaw Medical Univ, Wroclaw
Финансирање / пројекти:
- Интерактивна улога дислипидемије, оксидативног стреса и инфламације у атеросклерози и другим болестима: генетички и биохемијски маркери (RS-MESTD-Basic Research (BR or ON)-175035)
DOI: 10.17219/acem/37226
ISSN: 1899-5276
PubMed: 25166442
WoS: 000344634400011
Scopus: 2-s2.0-84909640201
Институција/група
PharmacyTY - JOUR AU - Ardalić, Daniela AU - Stefanović, Aleksandra AU - Kotur-Stevuljević, Jelena AU - Vujović, Ana AU - Spasić, Slavica AU - Spasojević-Kalimanovska, Vesna AU - Jelić-Ivanović, Zorana AU - Mandić-Marković, Vesna AU - Miković, Željko AU - Cerović, Nikola PY - 2014 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2143 AB - Background. As a physiological condition closely linked with increased susceptibility to oxidative stress, pregnancy can be further compromised by cigarette smoking. Inadequate nutrition and reduced intake of antioxidants can also disrupt the prooxidant/antioxidant relationship and contribute to oxidative stress. Increased oxidative stress during pregnancy may be involved in several complications of pregnancy, such as preterm labor, fetal growth restriction, preeclampsia and Miscarriage. Objectives. The aim of this study was to investigate the influence of maternal smoking habits before pregnancy on the parameters of oxidative stress and the antioxidative defense system, lipid profile parameters and paraoxonase-1 (PON1) activity during the third trimester of uncomplicated pregnancies. Material and Methods. Healthy pregnant women (n = 86) were divided into non-smoking and smoking groups, and into groups taking vitamin supplements and not taking them. Oxidative damage was measured through the levels of thiobarbituric acid-reacting substances (TBARS) and plasma antioxidant status was evaluated by measuring total antioxidant capacity (TAC). Results. TBARS concetration was significantly higher (p lt 0.05) and PON1 activity was significantly lower (p lt 0.05) in the smokers' group. No significant differences were found in the investigated parameters in relation to vitamin supplement intake. Conclusions. Habitual smoking before pregnancy is associated with increased oxidative stress. Vitamin supplementation has no effect on the oxidative stress status of healthy pregnant women. PB - Wroclaw Medical Univ, Wroclaw T2 - Advances in Clinical and Experimental Medicine T1 - The Influence of Maternal Smoking Habits Before Pregnancy and Antioxidative Supplementation During Pregnancy on Oxidative Stress Status in a Non-Complicated Pregnancy VL - 23 IS - 4 SP - 575 EP - 583 DO - 10.17219/acem/37226 ER -
@article{ author = "Ardalić, Daniela and Stefanović, Aleksandra and Kotur-Stevuljević, Jelena and Vujović, Ana and Spasić, Slavica and Spasojević-Kalimanovska, Vesna and Jelić-Ivanović, Zorana and Mandić-Marković, Vesna and Miković, Željko and Cerović, Nikola", year = "2014", abstract = "Background. As a physiological condition closely linked with increased susceptibility to oxidative stress, pregnancy can be further compromised by cigarette smoking. Inadequate nutrition and reduced intake of antioxidants can also disrupt the prooxidant/antioxidant relationship and contribute to oxidative stress. Increased oxidative stress during pregnancy may be involved in several complications of pregnancy, such as preterm labor, fetal growth restriction, preeclampsia and Miscarriage. Objectives. The aim of this study was to investigate the influence of maternal smoking habits before pregnancy on the parameters of oxidative stress and the antioxidative defense system, lipid profile parameters and paraoxonase-1 (PON1) activity during the third trimester of uncomplicated pregnancies. Material and Methods. Healthy pregnant women (n = 86) were divided into non-smoking and smoking groups, and into groups taking vitamin supplements and not taking them. Oxidative damage was measured through the levels of thiobarbituric acid-reacting substances (TBARS) and plasma antioxidant status was evaluated by measuring total antioxidant capacity (TAC). Results. TBARS concetration was significantly higher (p lt 0.05) and PON1 activity was significantly lower (p lt 0.05) in the smokers' group. No significant differences were found in the investigated parameters in relation to vitamin supplement intake. Conclusions. Habitual smoking before pregnancy is associated with increased oxidative stress. Vitamin supplementation has no effect on the oxidative stress status of healthy pregnant women.", publisher = "Wroclaw Medical Univ, Wroclaw", journal = "Advances in Clinical and Experimental Medicine", title = "The Influence of Maternal Smoking Habits Before Pregnancy and Antioxidative Supplementation During Pregnancy on Oxidative Stress Status in a Non-Complicated Pregnancy", volume = "23", number = "4", pages = "575-583", doi = "10.17219/acem/37226" }
Ardalić, D., Stefanović, A., Kotur-Stevuljević, J., Vujović, A., Spasić, S., Spasojević-Kalimanovska, V., Jelić-Ivanović, Z., Mandić-Marković, V., Miković, Ž.,& Cerović, N.. (2014). The Influence of Maternal Smoking Habits Before Pregnancy and Antioxidative Supplementation During Pregnancy on Oxidative Stress Status in a Non-Complicated Pregnancy. in Advances in Clinical and Experimental Medicine Wroclaw Medical Univ, Wroclaw., 23(4), 575-583. https://doi.org/10.17219/acem/37226
Ardalić D, Stefanović A, Kotur-Stevuljević J, Vujović A, Spasić S, Spasojević-Kalimanovska V, Jelić-Ivanović Z, Mandić-Marković V, Miković Ž, Cerović N. The Influence of Maternal Smoking Habits Before Pregnancy and Antioxidative Supplementation During Pregnancy on Oxidative Stress Status in a Non-Complicated Pregnancy. in Advances in Clinical and Experimental Medicine. 2014;23(4):575-583. doi:10.17219/acem/37226 .
Ardalić, Daniela, Stefanović, Aleksandra, Kotur-Stevuljević, Jelena, Vujović, Ana, Spasić, Slavica, Spasojević-Kalimanovska, Vesna, Jelić-Ivanović, Zorana, Mandić-Marković, Vesna, Miković, Željko, Cerović, Nikola, "The Influence of Maternal Smoking Habits Before Pregnancy and Antioxidative Supplementation During Pregnancy on Oxidative Stress Status in a Non-Complicated Pregnancy" in Advances in Clinical and Experimental Medicine, 23, no. 4 (2014):575-583, https://doi.org/10.17219/acem/37226 . .