Biopharmaceutical characterisation of ciprofloxacin-metallic ion interactions: Comparative study into the effect of aluminium, calcium, zinc and iron on drug solubility and dissolution
2014
Аутори
Stojković, AleksandraTajber, Lidia
Paluch, Krzysztof J.
Đurić, Zorica
Parojčić, Jelena
Corrigan, Owen I.
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Ciprofloxacin bioavailability may be reduced when ciprofloxacin is co-administered with metallic ion containing preparations. In our previous study, physicochemical interaction between ciprofloxacin and ferrous sulphate was successfully simulated in vitro. In the present work, comparative in vitro ciprofloxacin solubility and dissolution studies were performed in the reactive media containing aluminium hydroxide, calcium carbonate or zinc sulphate. Solid phases collected from the dissolution vessel with aluminium hydroxide, calcium carbonate and zinc sulphate were investigated for their properties. The results obtained indicate that different types of adducts may form and retard ciprofloxacin solubility and dissolution. In the case of aluminium, no phase changes were observed. The solid phase generated in the presence of calcium carbonate was identified as hydrated ciprofloxacin base. Similarly to iron, a new complex consistent with Zn(SO4)(2)(Cl)(2)(ciprofloxacin)(2) x nH(2)O stoichio...metry was generated in the presence of relatively high concentrations of ciprofloxacin hydrochloride and zinc sulphate, indicating that small volume dissolution experiments can be useful for biorelevant dissolution tests.
Кључне речи:
ciprofloxacin / dissolution / drug interactions / solubility / solid state characterisationИзвор:
Acta Pharmaceutica, 2014, 64, 1, 77-88Издавач:
- Hrvatsko Farmaceutsko Drustov (HFD)-Croation Pharmaceutical Soc, Zagreb
Финансирање / пројекти:
- Развој производа и технологија које обезбеђују жељено ослобађање лековитих супстанци из чврстих фармацеутских облика (RS-MESTD-Technological Development (TD or TR)-34007)
DOI: 10.2478/acph-2014-0007
ISSN: 1330-0075
PubMed: 24670353
WoS: 000333910300006
Scopus: 2-s2.0-84904178325
Институција/група
PharmacyTY - JOUR AU - Stojković, Aleksandra AU - Tajber, Lidia AU - Paluch, Krzysztof J. AU - Đurić, Zorica AU - Parojčić, Jelena AU - Corrigan, Owen I. PY - 2014 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2161 AB - Ciprofloxacin bioavailability may be reduced when ciprofloxacin is co-administered with metallic ion containing preparations. In our previous study, physicochemical interaction between ciprofloxacin and ferrous sulphate was successfully simulated in vitro. In the present work, comparative in vitro ciprofloxacin solubility and dissolution studies were performed in the reactive media containing aluminium hydroxide, calcium carbonate or zinc sulphate. Solid phases collected from the dissolution vessel with aluminium hydroxide, calcium carbonate and zinc sulphate were investigated for their properties. The results obtained indicate that different types of adducts may form and retard ciprofloxacin solubility and dissolution. In the case of aluminium, no phase changes were observed. The solid phase generated in the presence of calcium carbonate was identified as hydrated ciprofloxacin base. Similarly to iron, a new complex consistent with Zn(SO4)(2)(Cl)(2)(ciprofloxacin)(2) x nH(2)O stoichiometry was generated in the presence of relatively high concentrations of ciprofloxacin hydrochloride and zinc sulphate, indicating that small volume dissolution experiments can be useful for biorelevant dissolution tests. PB - Hrvatsko Farmaceutsko Drustov (HFD)-Croation Pharmaceutical Soc, Zagreb T2 - Acta Pharmaceutica T1 - Biopharmaceutical characterisation of ciprofloxacin-metallic ion interactions: Comparative study into the effect of aluminium, calcium, zinc and iron on drug solubility and dissolution VL - 64 IS - 1 SP - 77 EP - 88 DO - 10.2478/acph-2014-0007 ER -
@article{ author = "Stojković, Aleksandra and Tajber, Lidia and Paluch, Krzysztof J. and Đurić, Zorica and Parojčić, Jelena and Corrigan, Owen I.", year = "2014", abstract = "Ciprofloxacin bioavailability may be reduced when ciprofloxacin is co-administered with metallic ion containing preparations. In our previous study, physicochemical interaction between ciprofloxacin and ferrous sulphate was successfully simulated in vitro. In the present work, comparative in vitro ciprofloxacin solubility and dissolution studies were performed in the reactive media containing aluminium hydroxide, calcium carbonate or zinc sulphate. Solid phases collected from the dissolution vessel with aluminium hydroxide, calcium carbonate and zinc sulphate were investigated for their properties. The results obtained indicate that different types of adducts may form and retard ciprofloxacin solubility and dissolution. In the case of aluminium, no phase changes were observed. The solid phase generated in the presence of calcium carbonate was identified as hydrated ciprofloxacin base. Similarly to iron, a new complex consistent with Zn(SO4)(2)(Cl)(2)(ciprofloxacin)(2) x nH(2)O stoichiometry was generated in the presence of relatively high concentrations of ciprofloxacin hydrochloride and zinc sulphate, indicating that small volume dissolution experiments can be useful for biorelevant dissolution tests.", publisher = "Hrvatsko Farmaceutsko Drustov (HFD)-Croation Pharmaceutical Soc, Zagreb", journal = "Acta Pharmaceutica", title = "Biopharmaceutical characterisation of ciprofloxacin-metallic ion interactions: Comparative study into the effect of aluminium, calcium, zinc and iron on drug solubility and dissolution", volume = "64", number = "1", pages = "77-88", doi = "10.2478/acph-2014-0007" }
Stojković, A., Tajber, L., Paluch, K. J., Đurić, Z., Parojčić, J.,& Corrigan, O. I.. (2014). Biopharmaceutical characterisation of ciprofloxacin-metallic ion interactions: Comparative study into the effect of aluminium, calcium, zinc and iron on drug solubility and dissolution. in Acta Pharmaceutica Hrvatsko Farmaceutsko Drustov (HFD)-Croation Pharmaceutical Soc, Zagreb., 64(1), 77-88. https://doi.org/10.2478/acph-2014-0007
Stojković A, Tajber L, Paluch KJ, Đurić Z, Parojčić J, Corrigan OI. Biopharmaceutical characterisation of ciprofloxacin-metallic ion interactions: Comparative study into the effect of aluminium, calcium, zinc and iron on drug solubility and dissolution. in Acta Pharmaceutica. 2014;64(1):77-88. doi:10.2478/acph-2014-0007 .
Stojković, Aleksandra, Tajber, Lidia, Paluch, Krzysztof J., Đurić, Zorica, Parojčić, Jelena, Corrigan, Owen I., "Biopharmaceutical characterisation of ciprofloxacin-metallic ion interactions: Comparative study into the effect of aluminium, calcium, zinc and iron on drug solubility and dissolution" in Acta Pharmaceutica, 64, no. 1 (2014):77-88, https://doi.org/10.2478/acph-2014-0007 . .