Effect of small changes in natural origin-based emulsion systems on hydrocortisone skin absorption and performance: a comparison of two in vivo methods
Само за регистроване кориснике
2014
Аутори
Pantelić, IvanaLukić, Milica
Marković, Bojan
Daniels, Rolf
Vesić, Sonja
Vuleta, Gordana
Savić, Snežana
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Context: Alkyl polyglucoside surfactants (APG) remain prominent natural origin stabilizers offering a prospect of combining satisfactory stability with mild dermatological properties and complete biodegradability. Objective: With the purpose of adjusting the dose to a patient's needs, dilution of commercial corticosteroid formulations is a practice which may modify efficacy uncontrolledly. The rational of the study was to investigate whether a simple change in ready-to-use bases (co-solvent addition) could address these needs in a more predictive manner. Methods: Hydrocortisone (HC) delivery from such emulsion systems was comparatively assessed employing two in vivo methods: the established human skin blanching assay versus skin stripping technique. Results: HC permeation data obtained after three dose durations showed better overall performance of the APG-stabilized bases relative to reference ones. Although the solubility study showed that all the assessed active samples retained equ...al thermodynamic activity, diverse HC permeation/penetration implies the importance of the applied base's colloidal structure and/or changes endured. Isopropyl alcohol (IPA) addition offered faster drug penetration enhancement, while glycerol as a moisturizing agent influenced HC penetration through the increase in skin hydration. Conclusion: Although the performed in vivo methods cannot be considered alternative, skin stripping technique proved to be a cost-efficient mode of percutaneous penetration assessment, providing additional information on vehicle-skin interactions.
Кључне речи:
Alkyl polyglucosides / penetration enhancers / skin blanching assay / skin hydration / skin strippingИзвор:
Pharmaceutical Development and Technology, 2014, 19, 1, 55-64Издавач:
- Taylor & Francis Ltd, Abingdon
Финансирање / пројекти:
DOI: 10.3109/10837450.2012.751407
ISSN: 1083-7450
PubMed: 23259632
WoS: 000328132200007
Scopus: 2-s2.0-84899963035
Институција/група
PharmacyTY - JOUR AU - Pantelić, Ivana AU - Lukić, Milica AU - Marković, Bojan AU - Daniels, Rolf AU - Vesić, Sonja AU - Vuleta, Gordana AU - Savić, Snežana PY - 2014 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2177 AB - Context: Alkyl polyglucoside surfactants (APG) remain prominent natural origin stabilizers offering a prospect of combining satisfactory stability with mild dermatological properties and complete biodegradability. Objective: With the purpose of adjusting the dose to a patient's needs, dilution of commercial corticosteroid formulations is a practice which may modify efficacy uncontrolledly. The rational of the study was to investigate whether a simple change in ready-to-use bases (co-solvent addition) could address these needs in a more predictive manner. Methods: Hydrocortisone (HC) delivery from such emulsion systems was comparatively assessed employing two in vivo methods: the established human skin blanching assay versus skin stripping technique. Results: HC permeation data obtained after three dose durations showed better overall performance of the APG-stabilized bases relative to reference ones. Although the solubility study showed that all the assessed active samples retained equal thermodynamic activity, diverse HC permeation/penetration implies the importance of the applied base's colloidal structure and/or changes endured. Isopropyl alcohol (IPA) addition offered faster drug penetration enhancement, while glycerol as a moisturizing agent influenced HC penetration through the increase in skin hydration. Conclusion: Although the performed in vivo methods cannot be considered alternative, skin stripping technique proved to be a cost-efficient mode of percutaneous penetration assessment, providing additional information on vehicle-skin interactions. PB - Taylor & Francis Ltd, Abingdon T2 - Pharmaceutical Development and Technology T1 - Effect of small changes in natural origin-based emulsion systems on hydrocortisone skin absorption and performance: a comparison of two in vivo methods VL - 19 IS - 1 SP - 55 EP - 64 DO - 10.3109/10837450.2012.751407 ER -
@article{ author = "Pantelić, Ivana and Lukić, Milica and Marković, Bojan and Daniels, Rolf and Vesić, Sonja and Vuleta, Gordana and Savić, Snežana", year = "2014", abstract = "Context: Alkyl polyglucoside surfactants (APG) remain prominent natural origin stabilizers offering a prospect of combining satisfactory stability with mild dermatological properties and complete biodegradability. Objective: With the purpose of adjusting the dose to a patient's needs, dilution of commercial corticosteroid formulations is a practice which may modify efficacy uncontrolledly. The rational of the study was to investigate whether a simple change in ready-to-use bases (co-solvent addition) could address these needs in a more predictive manner. Methods: Hydrocortisone (HC) delivery from such emulsion systems was comparatively assessed employing two in vivo methods: the established human skin blanching assay versus skin stripping technique. Results: HC permeation data obtained after three dose durations showed better overall performance of the APG-stabilized bases relative to reference ones. Although the solubility study showed that all the assessed active samples retained equal thermodynamic activity, diverse HC permeation/penetration implies the importance of the applied base's colloidal structure and/or changes endured. Isopropyl alcohol (IPA) addition offered faster drug penetration enhancement, while glycerol as a moisturizing agent influenced HC penetration through the increase in skin hydration. Conclusion: Although the performed in vivo methods cannot be considered alternative, skin stripping technique proved to be a cost-efficient mode of percutaneous penetration assessment, providing additional information on vehicle-skin interactions.", publisher = "Taylor & Francis Ltd, Abingdon", journal = "Pharmaceutical Development and Technology", title = "Effect of small changes in natural origin-based emulsion systems on hydrocortisone skin absorption and performance: a comparison of two in vivo methods", volume = "19", number = "1", pages = "55-64", doi = "10.3109/10837450.2012.751407" }
Pantelić, I., Lukić, M., Marković, B., Daniels, R., Vesić, S., Vuleta, G.,& Savić, S.. (2014). Effect of small changes in natural origin-based emulsion systems on hydrocortisone skin absorption and performance: a comparison of two in vivo methods. in Pharmaceutical Development and Technology Taylor & Francis Ltd, Abingdon., 19(1), 55-64. https://doi.org/10.3109/10837450.2012.751407
Pantelić I, Lukić M, Marković B, Daniels R, Vesić S, Vuleta G, Savić S. Effect of small changes in natural origin-based emulsion systems on hydrocortisone skin absorption and performance: a comparison of two in vivo methods. in Pharmaceutical Development and Technology. 2014;19(1):55-64. doi:10.3109/10837450.2012.751407 .
Pantelić, Ivana, Lukić, Milica, Marković, Bojan, Daniels, Rolf, Vesić, Sonja, Vuleta, Gordana, Savić, Snežana, "Effect of small changes in natural origin-based emulsion systems on hydrocortisone skin absorption and performance: a comparison of two in vivo methods" in Pharmaceutical Development and Technology, 19, no. 1 (2014):55-64, https://doi.org/10.3109/10837450.2012.751407 . .